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BAALC Knockout Cell Lines

Gene: BAALC

Official Full Name: BAALC binder of MAP3K1 and KLF4provided by HGNC

Gene Summary: This gene was identified by gene expression studies in patients with acute myeloid leukemia (AML). The gene is conserved among mammals and is not found in lower organisms. Tissues that express this gene develop from the neuroectoderm. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene; however, some of the transcript variants are found only in AML cell lines. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03221 BAALC Knockout cell line (HEK293) Human BAALC 1:3~1:6 Negative Online Inquiry

Background

BAALC Gene Knockout Cell Lines are genetically modified cellular systems created specifically to study the function of the BAALC (Brain Abundant Abnormalisly Expressed Sequence 1) gene, which is implicated in various hematological malignancies. These cell lines exhibit a complete knockout of the BAALC gene, allowing researchers to investigate the phenotypic and molecular consequences of its absence in a controlled environment. By utilizing advanced CRISPR/Cas9 technology, the BAALC Gene Knockout Cell Lines facilitate precise gene editing, ensuring high fidelity in knockdown efficiency and cellular viability.

The key function of these cell lines enables the dissection of the BAALC gene's role in cellular signaling pathways, gene expression regulation, and its impact on cell proliferation and differentiation. Such insights are crucial for understanding the mechanisms underlying disease states such as leukemia, where abnormal BAALC expression may serve as a biomarker or therapeutic target. Consequently, these cell lines are invaluable tools for drug development and testing, allowing for the evaluation of potential therapeutic agents in a relevant biological context.

Compared to traditional non-modified cell lines, the BAALC Gene Knockout Cell Lines offer a significant advantage by providing researchers with a model that closely mimics the genetic aberrations observed in patient samples. This specificity enhances the translational potential of research findings, bridging fundamental studies and clinical applications more effectively than alternative models. Additionally, the reproducibility of results obtained from such engineered systems increases the reliability of experimental outcomes.

As a product developed by leading experts in genetic engineering and cell line development, our BAALC Gene Knockout Cell Lines underscore our commitment to supporting scientific advancement. Researchers and clinicians will find these cell lines essential for dissecting the complexities of BAALC-related pathologies, promoting innovative solutions in cancer research and offering impactful contributions to the field of molecular biology. Our company’s expertise in cell line development and dedication to quality ensures that you are equipped with superior tools for your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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