Gene: ATF5
Official Full Name: activating transcription factor 5provided by HGNC
Gene Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and tubulin binding activity. Involved in several processes, including fat cell differentiation; regulation of DNA-templated transcription; and regulation of cell cycle process. Located in centrosome; cytosol; and nucleoplasm. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00500 | ATF5 knockout cell line (A549) | Human | ATF5 | 1:3~1:4 | Negative | Online Inquiry |
KO04675 | ATF5 Knockout cell line (HeLa) | Human | ATF5 | 1:3~1:6 | Negative | Online Inquiry |
KO04676 | ATF5 Knockout cell line (HCT 116) | Human | ATF5 | 1:2~1:4 | Negative | Online Inquiry |
KO04677 | ATF5 Knockout cell line (HEK293) | Human | ATF5 | 1:3~1:6 | Negative | Online Inquiry |
ATF5 Gene Knockout Cell Lines are specialized cellular models in which the ATF5 gene has been systematically disrupted to study its role in cellular functions and disease mechanisms. The ATF5 gene encodes a transcription factor involved in regulating stress response, cellular differentiation, and apoptosis. By creating knockout lines, researchers can observe phenotypic changes and elucidate the pathways impacted by the absence of ATF5, ultimately enhancing our understanding of its biological significance.
These cell lines utilize CRISPR-Cas9 technology to ensure precise gene editing, leading to effective and reproducible knockout efficiency. The absence of ATF5 allows scientists to investigate its implications in conditions such as neurodegenerative disorders, cancer, and metabolic syndromes, where altered stress responses and cellular homeostasis are critical. The potential applications are vast, offering insights into gene function, cell signaling pathways, and identifying novel therapeutic targets.
One of the primary advantages of our ATF5 Gene Knockout Cell Lines is the robust validation of gene modification, coupled with a thorough characterization of cellular responses. This sets them apart from alternative models, which may not provide the same level of specificity or reliability. Furthermore, our cell lines are readily available for researchers, saving them valuable time in creating their own knockout models.
For researchers and clinicians alike, the ATF5 Gene Knockout Cell Lines present a powerful tool to delve into gene function and unravel complex biological mechanisms. They can integrate seamlessly into existing experimental workflows, facilitating rigorous testing and validation of hypotheses related to ATF5 and its associated pathways.
Our company specializes in providing cutting-edge biological products backed by comprehensive scientific knowledge and rigorous quality control. With expertise in genetic engineering and cell line development, we aim to empower the scientific community with reliable solutions to advance research and therapeutic strategies.
Please note that all services are for research use only. Not intended for any clinical use.
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