Gene: ARHGAP24
Official Full Name: Rho GTPase activating protein 24provided by HGNC
Gene Summary: This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25479 | ARHGAP24 Knockout cell line (HEK293) | Human | ARHGAP24 | 1:3~1:6 | Negative | Online Inquiry |
KO25480 | ARHGAP24 Knockout cell line (A549) | Human | ARHGAP24 | 1:3~1:4 | Negative | Online Inquiry |
ARHGAP24 Gene Knockout Cell Lines are precisely engineered cellular models designed to investigate the functional role of the ARHGAP24 gene, which encodes a Rho GTPase-activating protein. This gene plays a crucial part in regulating cellular processes such as cytoskeletal dynamics, cell migration, and proliferation by modulating Rho family GTPases. With the knockout of ARHGAP24, these cell lines provide a unique experimental platform to dissect the molecular pathways affected by its absence, facilitating a deeper understanding of its contributions to various physiological and pathological states.
The key mechanism of action involves the loss of ARHGAP24 expression, which alters downstream signaling pathways associated with cell motility and adhesion. The implications of this change are significant; researchers can explore how the knockout influences various cellular behaviors, including cancer cell invasion, tissue morphogenesis, and immune cell functions. This capacity to elucidate ARHGAP24's role enhances its relevance in both fundamental research and translational studies, particularly in cancer biology, neurological disorders, and tissue development.
Compared to alternative models, the ARHGAP24 Gene Knockout Cell Lines stand out due to their precise genetic modification, allowing for specific and reproducible results that closely mimic physiological conditions. The targeted gene knockout minimizes off-target effects often seen with other methods, such as pharmacological inhibition or transient knockdown approaches, thus providing a reliable substrate for experimentation.
For researchers and clinicians focused on understanding the complexities of gene function and disease mechanisms, the ARHGAP24 Gene Knockout Cell Lines represent an invaluable tool. They not only advance the mechanistic inquiry into gene function but also have potential implications for therapeutic strategies targeting ARHGAP24-related pathways.
Our company specializes in the development of innovative bioresearch tools, and our expertise in gene manipulation technologies ensures that products like the ARHGAP24 Gene Knockout Cell Lines meet the highest standards of quality and efficacy, empowering the scientific community to push the frontiers of biological knowledge.
Please note that all services are for research use only. Not intended for any clinical use.
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