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ADK Knockout Cell Lines

Gene: ADK

Official Full Name: adenosine kinaseprovided by HGNC

Gene Summary: This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02026 ADK Knockout cell line (HeLa) Human ADK 1:3~1:6 Negative Online Inquiry
KO02027 ADK Knockout cell line (HCT 116) Human ADK 1:2~1:4 Negative Online Inquiry
KO02028 ADK Knockout cell line (HEK293) Human ADK 1:3~1:6 Negative Online Inquiry
KO02029 ADK Knockout cell line (A549) Human ADK 1:3~1:4 Negative Online Inquiry

Background

ADK Gene Knockout Cell Lines represent a cutting-edge tool in genetic research and therapeutic development. These cell lines are engineered to possess a targeted deletion of the adenosine kinase (ADK) gene, which encodes for the enzyme responsible for the phosphorylation of adenosine, a critical regulator of cellular signaling and metabolism. By completely knocking out this gene, researchers can observe the ensuing phenotypic changes, providing insights into ADK's role in various biological processes, including energy metabolism, cell proliferation, and apoptosis.

The key function of the ADK Gene Knockout Cell Lines lies in their unique ability to mimic pathological conditions where adenosine signaling is altered, such as in cancer, inflammation, and neurodegenerative diseases. By utilizing these cell lines, scientists can dissect the underlying mechanisms of ADK's involvement in these diseases, paving the way for the discovery of novel therapeutic strategies. The ability to observe changes in cellular behavior in these knockout models is invaluable, as it allows for a clearer understanding of adenosine's impact in both normal and diseased states.

In clinical and research settings, the significance of these cell lines cannot be overstated. They serve as a vital component for drug development and screening, enabling a more accurate evaluation of therapeutic candidates targeting adenosine pathways. Additionally, these knockout lines facilitate the exploration of potential biomarkers for disease states, making them a critical asset in translational research.

What sets our ADK Gene Knockout Cell Lines apart from alternatives is their high specificity, ease of use, and the robust scientific validation underpinning their development. Unlike generalized cell lines, our product allows for precise investigations of the ADK gene's role, thereby reducing the likelihood of extraneous results and enhancing research accuracy. Furthermore, our commitment to quality ensures that each cell line is thoroughly characterized and validated, resulting in dependable data for researchers.

For researchers and clinicians aiming to push boundaries in understanding cellular metabolism and therapeutic responses, ADK Gene Knockout Cell Lines are a valuable resource. They empower users to conduct sophisticated studies with unparalleled precision. With years of experience in the field of genetic engineering, our company is dedicated to providing high-quality biological products that meet the intricate demands of modern research. We pride ourselves on fostering innovation through our expert-driven product offerings and cutting-edge laboratory techniques.

Please note that all services are for research use only. Not intended for any clinical use.

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