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ABRAXAS2 Knockout Cell Lines

Gene: ABRAXAS2

Official Full Name: abraxas 2, BRISC complex subunitprovided by HGNC

Gene Summary: Enables microtubule binding activity and polyubiquitin modification-dependent protein binding activity. Involved in nuclear chromosome segregation; protein K63-linked deubiquitination; and response to ischemia. Located in cytoplasm; microtubule cytoskeleton; and midbody. Part of BRISC complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29730 ABRAXAS2 Knockout cell line (HeLa) Human ABRAXAS2 1:3~1:6 Negative Online Inquiry
KO29731 ABRAXAS2 Knockout cell line (HCT 116) Human ABRAXAS2 1:2~1:4 Negative Online Inquiry
KO29732 ABRAXAS2 Knockout cell line (HEK293) Human ABRAXAS2 1:3~1:6 Negative Online Inquiry
KO29733 ABRAXAS2 Knockout cell line (A549) Human ABRAXAS2 1:3~1:4 Negative Online Inquiry

Background

ABRAXAS2 Gene Knockout Cell Lines are genetically engineered cellular models designed to enable precise studies of the ABRAXAS2 gene, a critical player in DNA damage response and tumor suppression. By applying CRISPR/Cas9 technology, these cell lines have been meticulously developed to facilitate the examination of ABRAXAS2 function through targeted gene disruption, thus allowing researchers to assess the role of this gene in cellular processes such as genomic stability, repair mechanisms, and cancer progression.

The primary mechanism of action involves the knockout of the ABRAXAS2 gene, leading to an altered phenotype that provides insights into the biological pathways influenced by this gene. These cell lines can be utilized to explore gene function in various contexts, enabling researchers to study the effects of ABRAXAS2 lack in cellular stress responses, apoptosis, and signal transduction pathways. The ability to conduct such detailed investigations supports the development of targeted therapies in oncology and the investigation of genetic disorders linked to DNA repair deficiencies.

In both research and clinical settings, the ABRAXAS2 Gene Knockout Cell Lines offer significant advantages over traditional models. They provide a clean genetic background while eliminating confounding variables, ensuring reproducibility and reliability in experiments. As a result, they enable more straightforward evaluation of gene function and drug responses, streamlining the translation of findings from bench to bedside. Their usage is pivotal for scientists working on cutting-edge projects aimed at understanding cancer etiology or improving precision medicine strategies.

Researchers and clinicians can appreciate the unique value of these cell lines, as they not only enhance experimental accuracy but also pave the way for innovative therapeutic developments targeting the DNA damage response pathway. Our company brings deep expertise in gene editing technologies and has a proven track record of delivering high-quality biological products that empower the scientific community. The ABRAXAS2 Gene Knockout Cell Lines are a testament to our commitment to advancing research and improving human health through precise genetic modeling.

Please note that all services are for research use only. Not intended for any clinical use.

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