CDKN2B Knockout cell line (HeLa)

Catalog Number: KO08182

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Specifications

Product Information
Product Name	CDKN2B Knockout cell line (HeLa)
specification	1*10^6
Storage and transportation	Dry ice preservation/T25 live cell transportation.
Cell morphology	Epithelioid, adherent cell
Passage ratio	1:3~1:6
species	Human
Gene	CDKN2B
Gene ID	1030
Build method	Electric rotation method / virus method
Mycoplasma testing	Negative
Cultivation system	90%DMEM+10% FBS
Parental Cell Line	HeLa
Quality Control	Genotype: CDKN2B Knockout cell line (HeLa) >95% viability before freezing. All cells were tested and found to be free of bacterial, viruses,mycoplasma and other toxins.

Gene Information
Gene Official Full Name	cyclin dependent kinase inhibitor 2Bprovided by HGNC
Also known as	P15; MTS2; TP15; CDK4I; INK4B; p15INK4b
Gene Description	This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Expression	Broad expression in colon (RPKM 20.3), small intestine (RPKM 17.6) and 17 other tissues See more

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