Gene: CBFA2T3
Official Full Name: CBFA2/RUNX1 partner transcriptional co-repressor 3provided by HGNC
Gene Summary: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38685 | CBFA2T3 Knockout cell line (HCT 116) | Human | CBFA2T3 | 1:2~1:4 | Negative | Online Inquiry |
CBFA2T3 Gene Knockout Cell Lines are specialized biological tools used for the functional characterization of the CBFA2T3 gene, which is implicated in various cellular processes such as differentiation and proliferation. These cell lines provide a crucial resource for researchers aiming to investigate the phenotypic and genotypic consequences of CBFA2T3 gene deletion, facilitating in-depth studies on its role in diseases such as leukemia and other hematological disorders.
The key functions of these knockout cell lines revolve around the ability to unravel the molecular mechanisms involved in the signaling pathways affected by the absence of the CBFA2T3 gene. Researchers can assess alterations in gene expression, cellular metabolism, and the impact on lineage commitment, providing invaluable insights into the tumorigenesis process and potential therapeutic targets.
From a scientific perspective, the CBFA2T3 Gene Knockout Cell Lines hold significant promise in both basic research and clinical applications. They serve as vital models for elucidating the gene's contribution to cancer progression and for evaluating the efficacy of novel pharmacological interventions. Their relevance in preclinical studies cannot be overstated, as they allow for the validation of hypotheses related to gene function and disease mechanisms.
What sets our CBFA2T3 Gene Knockout Cell Lines apart from alternatives is the rigor in our cell line development process. Each line undergoes stringent validation steps to confirm gene knockout efficiency and ensure stability across multiple passages. Additionally, our lines are developed using cutting-edge CRISPR technology, ensuring high specificity and low off-target effects, which are critical for reliable experimental results.
For researchers and clinicians, these knockout cell lines represent a valuable asset, delivering a robust platform for investigating the functional implications of gene loss. Our commitment to quality and innovation extends beyond the product; it encompasses our extensive support services, which include comprehensive data sharing and troubleshooting assistance to maximize the utility of our products.
With a rich background in developing advanced biological research tools, our company stands at the forefront of genetic research, dedicated to empowering scientists and advancing the field of molecular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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