CASP10 Knockout cell line (NCM460)

Catalog Number: KOA78423

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Specifications

Product Information
Product Name	CASP10 Knockout cell line (NCM460)
specification	1*10^6
Storage and transportation	Shipped on dry ice; Store in liquid nitrogen
Cell morphology	Epithelial-like, adheren
Passage ratio	1:2~1:3
species	Human
Gene	CASP10
Gene ID	843
Build method	Electroporation/Lentivirus
Mycoplasma testing	negative
Cultivation system	90%RPMI-1640+10%FBS
Parental Cell Line	NCM460
Quality Control	Genotype: CASP10 Knockout cell line (NCM460)>95% viability before freezing. All cells were tested and found to be free of bacterial, viruses,mycoplasma and other toxins.

Gene Information
Gene Official Full Name	caspase 10provided by HGNC
Also known as	MCH4; ALPS2; FLICE2; FLICE-2
Gene Description	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Expression	Broad expression in duodenum (RPKM 6.6), spleen (RPKM 5.9) and 23 other tissues See more

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