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TENT2 Knockout Cell Lines

Gene: TENT2

Official Full Name: terminal nucleotidyltransferase 2provided by HGNC

Gene Summary: Enables poly(A) RNA polymerase activity. Involved in histone mRNA catabolic process; mRNA 3'-end processing; and negative regulation of miRNA catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of nuclear RNA-directed RNA polymerase complex. Predicted to be active in glutamatergic synapse; perforant pathway to dendrate granule cell synapse; and postsynapse. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13475 TENT2 Knockout cell line (HeLa) Human TENT2 1:3~1:6 Negative Online Inquiry
KO13476 TENT2 Knockout cell line (HCT 116) Human TENT2 1:2~1:4 Negative Online Inquiry
KO13477 TENT2 Knockout cell line (HEK293) Human TENT2 1:3~1:6 Negative Online Inquiry
KO13478 TENT2 Knockout cell line (A549) Human TENT2 1:3~1:4 Negative Online Inquiry

Background

TENT2 Gene Knockout Cell Lines are specially engineered cellular models that serve to investigate the functional role of the TENT2 gene, implicated in mRNA processing and stability. These cell lines have been created through precise genetic modification techniques, specifically CRISPR-Cas9, to render the TENT2 gene non-functional, allowing researchers to explore the downstream effects of its absence on cellular physiology.

The primary function of TENT2 involves its participation in poly(A) tail addition, which is crucial for mRNA stability and translation efficiency. By utilizing TENT2 Gene Knockout Cell Lines, scientists can dissect the molecular pathways governed by mRNA regulation and stability, shedding light on critical processes such as gene expression control and its potential link to various diseases, including cancer and neurodegenerative disorders.

The scientific importance of these knockout cell lines extends to both fundamental research and translational applications. In research settings, they are invaluable for elucidating the molecular mechanisms underlying TENT2's functions and for identifying potential therapeutic targets. Clinically, understanding TENT2's role can pave the way for novel interventions in mRNA-related diseases, offering hope for advancements in personalized medicine.

What sets TENT2 Gene Knockout Cell Lines apart from alternative models is their high specificity and reliability, coupled with the ease of use in a variety of experimental protocols. Unlike traditional gene knockdown approaches that may lead to incomplete inhibition, these knockout lines provide a definitive model, ensuring reproducible results and robust data.

For researchers and clinicians alike, the ability to study gene function in a controlled environment offers profound insights that can accelerate discoveries in the realms of biomedical research and therapeutic development. Our company, renowned for its expertise in cellular biology and genetic engineering, is committed to providing high-quality biological products that empower scientific advancement, making TENT2 Gene Knockout Cell Lines an essential tool for any laboratory focused on gene function and therapeutic exploration.

Please note that all services are for research use only. Not intended for any clinical use.

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