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RASGRF1 Knockout Cell Lines

Gene: RASGRF1

Official Full Name: Ras protein specific guanine nucleotide releasing factor 1provided by HGNC

Gene Summary: The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10516 RASGRF1 Knockout cell line (HCT 116) Human RASGRF1 1:2~1:4 Negative Online Inquiry

Background

RASGRF1 Gene Knockout Cell Lines are genetically modified cell lines characterized by the intentional disruption of the RASGRF1 gene, which plays a critical role in the regulation of RAS signaling pathways that are pivotal in cell growth, differentiation, and survival. By utilizing CRISPR-Cas9 technology, these cell lines provide researchers with a robust model to investigate the specific biological functions and regulatory mechanisms associated with RASGRF1.

The key mechanisms of action involve the targeted deletion of the RASGRF1 gene, effectively silencing its expression, which allows for a clearer understanding of its role in oncogenic processes and other cellular events. This knockout model facilitates the elucidation of downstream effects on RAS signaling, providing insights into how aberrations in this pathway could contribute to tumorigenesis or developmental disorders.

The scientific importance of RASGRF1 Gene Knockout Cell Lines lies in their versatility and application in both basic and applied research. They serve as invaluable tools in drug discovery and translational studies, potentially leading to breakthroughs in cancer therapeutics and personalized medicine approaches. These specialized cell lines can also be employed in the study of neurodevelopmental disorders, given the involvement of the RAS signaling pathway in neuronal growth and plasticity.

What sets our RASGRF1 Gene Knockout Cell Lines apart from alternatives is the precision of the knockout, validated through rigorous genomic and phenotypic analyses. Our cell lines exhibit reproducible and consistent results, providing a reliable resource for experimental designs and diminishing the variability often seen in wild-type models.

Researchers and clinicians are likely to find significant value in these knockout cell lines, as they enhance experimental efficiency, enabling in-depth investigations into disease mechanisms and therapeutic responses. The availability of well-characterized, high-quality cell lines accelerates research timelines and improves the reliability of data assessment.

Our company, with years of expertise in gene editing technology and a commitment to advancing biological science, delivers these specialized RASGRF1 Gene Knockout Cell Lines as part of our comprehensive product offering designed to support and drive forward innovative research in cellular and molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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