Home / PLAGL1 Knockout Cell Lines

PLAGL1 Knockout Cell Lines

Gene: PLAGL1

Official Full Name: PLAG1 like zinc finger 1provided by HGNC

Gene Summary: This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36040 PLAGL1 Knockout cell line (HeLa) Human PLAGL1 1:3~1:6 Negative Online Inquiry
KO36041 PLAGL1 Knockout cell line (HCT 116) Human PLAGL1 1:2~1:4 Negative Online Inquiry
KO36042 PLAGL1 Knockout cell line (HEK293) Human PLAGL1 1:3~1:6 Negative Online Inquiry
KO36043 PLAGL1 Knockout cell line (A549) Human PLAGL1 1:3~1:4 Negative Online Inquiry

Background

PLAGL1 Gene Knockout Cell Lines are advanced biological tools specifically designed to facilitate the study of the PLAGL1 gene's role in various cellular processes, such as growth regulation and differentiation. By utilizing CRISPR-Cas9 technology, these cell lines effectively disrupt the PLAGL1 gene, enabling researchers to examine the downstream effects of its absence on cellular function and signaling pathways.

The primary mechanism of action involves targeted gene editing, which leads to the complete knockout of the PLAGL1 gene. This process allows scientists to eliminate the expression of PLAGL1, providing a unique model to investigate its contribution to tumorigenesis, metabolic disorders, and developmental biology. The absence of PLAGL1 can lead to significant alterations in gene expression profiles and cellular behavior, making these knockout cell lines invaluable for elucidating the gene's multifaceted roles in health and disease.

The scientific importance of PLAGL1 Gene Knockout Cell Lines is underscored by their applicability in both basic research and potential therapeutic contexts. Researchers can leverage these lines to identify novel biomarkers and therapeutic targets, particularly relevant in cancer biology where PLAGL1 has been implicated. Furthermore, the versatility of these cell lines allows for various assays, such as drug response studies and in vivo modeling, enabling a deeper understanding of gene function.

A significant advantage of our PLAGL1 Gene Knockout Cell Lines is their robustness and ease of use compared to alternative models. Unlike traditional knockout strains, which may exhibit unintended genetic modifications, our cell lines are derived from well-characterized backgrounds ensuring reproducibility and reliability in experimental outcomes. Additionally, they come with comprehensive user protocols and support, facilitating seamless integration into ongoing research projects.

For researchers and clinicians, the value of these cell lines lies in their ability to accelerate scientific discovery and therapeutic advancements. By providing a reliable system to investigate the PLAGL1 gene, users can contribute to the growing body of knowledge on gene regulation and its implications in disease.

Our company is committed to advancing scientific research by delivering high-quality biological products, including these PLAGL1 Gene Knockout Cell Lines, backed by a team of experts dedicated to supporting your research needs.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.