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NPY Knockout Cell Lines

Gene: NPY

Official Full Name: neuropeptide Yprovided by HGNC

Gene Summary: This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00404 NPY gRNA3-gRNA4 KO plasmid NPY $850
KO07584 NPY Knockout cell line (HEK293) Human NPY 1:3~1:6 Negative Online Inquiry

Background

NPY Gene Knockout Cell Lines are genetically engineered cell models specifically designed to lack the neuropeptide Y (NPY) gene, which encodes a critical neuropeptide involved in various physiological processes such as appetite regulation, stress responses, and cardiovascular functions. These cell lines provide a platform for investigating the functional consequences of NPY deficiency, allowing researchers to elucidate the underlying mechanisms of metabolic disorders, neurodegenerative diseases, and stress-related conditions.

The primary function of NPY Gene Knockout Cell Lines involves the disruption of the NPY signaling pathway. By knocking out the NPY gene, researchers can assess changes in cellular behaviors, signaling cascades, and metabolic profiles compared to wild-type cell lines. This model facilitates the exploration of compensatory mechanisms or alternative pathways activated in the absence of NPY, providing valuable insights into its physiological and pathological roles.

The scientific importance of these cell lines is underscored by their applications in both basic research and clinical settings. They serve as a tool for drug discovery, enabling the development of therapeutic interventions targeting NPY-related pathways. Additionally, these cell lines can aid in investigating conditions such as obesity, anxiety, and depression, potentially leading to the identification of novel biomarkers or treatment strategies.

What sets NPY Gene Knockout Cell Lines apart is their specificity and precision. Unlike traditional methods that may offer a broader knockdown or less targeted approaches, these knockout models provide a complete ablation of the NPY gene, ensuring clear interpretation of results. This precision reduces experimental variability and increases the reliability of data, making them superior to alternative models.

For researchers and clinicians in fields such as pharmacology, neurology, and metabolic research, NPY Gene Knockout Cell Lines are invaluable for advancing understanding of NPY’s role in disease and facilitating the development of targeted therapies. Our company possesses extensive expertise in producing high-quality genetic models and is committed to supporting the scientific community with tools that drive innovative research and discovery. By choosing NPY Gene Knockout Cell Lines, you invest in a robust experimental framework that can help unlock new avenues in your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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