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MYB Knockout Cell Lines

Gene: MYB

Official Full Name: MYB proto-oncogene, transcription factorprovided by HGNC

Gene Summary: This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01401 MYB Knockout cell line (HeLa) Human MYB 1:3~1:6 Negative Online Inquiry
KO10218 MYB Knockout cell line (HCT 116) Human MYB 1:2~1:4 Negative Online Inquiry
KO10219 MYB Knockout cell line (HEK293) Human MYB 1:3~1:6 Negative Online Inquiry

Background

MYB Gene Knockout Cell Lines are a cutting-edge tool designed for the precise study of the MYB gene's role in cell biology and disease. These cell lines are engineered to have the MYB gene ablated through advanced CRISPR-Cas9 technology, allowing researchers to investigate the gene’s function, regulatory mechanisms, and impact on cellular pathways in a controlled environment.

The primary function of these knockout cell lines lies in their ability to mimic loss-of-function scenarios, providing insights into the biological roles of MYB, a transcription factor implicated in various cellular processes, including proliferation, differentiation, and apoptosis. By eliminating MYB expression, researchers can delve into its interactions with other genes and proteins, particularly in the context of hematopoietic malignancies and other cancers where MYB is known to play a critical role.

The scientific importance of MYB Gene Knockout Cell Lines extends to their applications in both basic and translational research. In laboratory settings, these lines serve as invaluable models for studying gene function, signaling pathways, and drug response. Clinically, they have the potential to aid in the development of targeted therapies by elucidating MYB’s contributions to tumorigenesis and disease progression.

What sets these knockout cell lines apart from other genetic engineering alternatives is their high efficiency and specificity. The CRISPR-Cas9 mediated approach minimizes off-target effects, ensuring that any observed phenotypic changes are attributable to the specific knockout of the MYB gene. This precision coupled with the reliability of cell line usage makes them preferable for experimental reproducibility.

Researchers and clinicians utilizing MYB Gene Knockout Cell Lines gain essential tools that not only enhance their understanding of gene function but also pave the way for advances in therapeutic strategies. With our company’s commitment to providing high-quality biological products backed by rigorous scientific validation, we empower researchers to achieve breakthroughs in gene therapy and cancer research. Our expertise ensures that each product meets the highest standards, facilitating advancements in life sciences and healthcare.

Please note that all services are for research use only. Not intended for any clinical use.

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