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MGLL Knockout Cell Lines

Gene: MGLL

Official Full Name: monoglyceride lipaseprovided by HGNC

Gene Summary: This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04205 MGLL Knockout cell line (HeLa) Human MGLL 1:3~1:6 Negative Online Inquiry
KO04206 MGLL Knockout cell line (HCT 116) Human MGLL 1:2~1:4 Negative Online Inquiry
KO04207 MGLL Knockout cell line (HEK293) Human MGLL 1:3~1:6 Negative Online Inquiry
KO04208 MGLL Knockout cell line (A549) Human MGLL 1:3~1:4 Negative Online Inquiry

Background

MGLL Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to silence the expression of the monoglyceride lipase (MGLL) gene. This gene encodes an enzyme that plays a pivotal role in the metabolism of endocannabinoids and other lipid-derived signaling molecules. By utilizing advanced CRISPR/Cas9 technology, these cell lines provide a powerful tool for researchers studying lipid metabolism, endocannabinoid signaling, and their implications in various physiological and pathological processes.

The primary function of MGLL Gene Knockout Cell Lines is to facilitate the elucidation of MGLL's role in lipid signaling and metabolic pathways. In the absence of MGLL, researchers can investigate compensatory mechanisms in lipid metabolism and assess changes in cannabinoid receptor activity, thereby informing potential therapeutic targets for conditions such as obesity, pain, and neurodegenerative disorders. These cell lines have been meticulously validated to ensure consistent knockout of the MGLL gene, allowing for reliable and reproducible experimental results.

The scientific importance of MGLL knockouts extends beyond basic research; they hold significant potential in clinical applications, particularly in pharmacology and toxicology. By evaluating how the absence of MGLL influences drug metabolism and efficacy, researchers can better predict drug interactions and optimize therapeutic regimens.

What sets our MGLL Gene Knockout Cell Lines apart from alternatives is their enhanced specificity and the precision with which the gene knockout is achieved, minimizing off-target effects that can confound results. Furthermore, our product has been developed with stringent quality controls and is backed by comprehensive user support, ensuring scientists spend less time troubleshooting and more time advancing their research.

For researchers, clinicians, and biotechnology companies focused on advancing the frontiers of biomedical science, the MGLL Gene Knockout Cell Lines represent an invaluable asset. They facilitate a deeper understanding of complex biological processes and contribute to the development of innovative therapies.

As a leader in biological products, our company is committed to delivering high-quality research tools backed by unparalleled expertise in genetic engineering and cell line development, empowering the scientific community towards greater breakthroughs.

Please note that all services are for research use only. Not intended for any clinical use.

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