Gene: EYA1
Official Full Name: EYA transcriptional coactivator and phosphatase 1provided by HGNC
Gene Summary: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated with branchiootorenal dysplasia syndrome, branchiootic syndrome, and sporadic cases of congenital cataracts and ocular anterior segment anomalies. A similar protein in mice can act as a transcriptional activator. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Dec 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04285 | EYA1 Knockout cell line (HeLa) | Human | EYA1 | 1:3~1:6 | Negative | Online Inquiry |
KO04286 | EYA1 Knockout cell line (HEK293) | Human | EYA1 | 1:3~1:6 | Negative | Online Inquiry |
EYA1 Gene Knockout Cell Lines are specialized cellular models engineered to lack the functional EYA1 gene, which encodes for a member of the Eya family of proteins involved in developmental processes and cellular signaling. This knockout specifically allows researchers to investigate the role of EYA1 in various biological contexts, including cell differentiation, proliferation, and apoptosis. The precise gene-editing techniques employed, such as CRISPR/Cas9, ensure the elimination of EYA1 expression, paving the way for in-depth studies into the molecular pathways influenced by this gene.
The key function of these knockout cell lines is to serve as a robust platform for elucidating the molecular mechanisms through which EYA1 interacts with other cellular components and influences gene expression. By comparing the knockout lines to their wild-type counterparts, scientists can identify the downstream effects of EYA1 absence on signal transduction pathways and its potential role in oncogenesis or developmental disorders. This research has significant implications for understanding diseases linked to EYA1 dysregulation, such as certain cancers and congenital defects.
Versatile and not confined to a single research field, EYA1 Gene Knockout Cell Lines are valuable in both fundamental and applied research settings. Compared to conventional wild-type cell lines, these knockout models provide a more accurate depiction of the biological effects of EYA1 deficiency, allowing for more nuanced experimental results. Additionally, they offer researchers a unique opportunity to test therapeutic interventions aimed at the restoration of EYA1 function or the inhibition of its pathological effects.
For researchers and clinicians, the availability of EYA1 Gene Knockout Cell Lines is an asset—empowering them to generate novel insights that can lead to breakthroughs in targeted therapies or disease prevention strategies. Our company specializes in producing high-quality biological products engineered for precision and reliability, ensuring that you receive tools that enhance your research capabilities and advance your scientific goals.
Please note that all services are for research use only. Not intended for any clinical use.
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