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ERBIN Knockout Cell Lines

Gene: ERBIN

Official Full Name: erbb2 interacting proteinprovided by HGNC

Gene Summary: This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04620 ERBIN Knockout cell line (HeLa) Human ERBIN 1:3~1:6 Negative Online Inquiry
KO04621 ERBIN Knockout cell line (HCT 116) Human ERBIN 1:2~1:4 Negative Online Inquiry
KO04622 ERBIN Knockout cell line (HEK293) Human ERBIN 1:3~1:6 Negative Online Inquiry
KO04623 ERBIN Knockout cell line (A549) Human ERBIN 1:3~1:4 Negative Online Inquiry

Background

ERBIN Gene Knockout Cell Lines represent a sophisticated tool in genetic research, built upon the technology of genome editing to specifically inactivate the ERBIN gene. These cell lines are meticulously engineered to facilitate the study of gene function and its associated pathways, providing researchers with a robust model to investigate the physiological and pathological roles of ERBIN. Utilizing CRISPR-Cas9 technology, each cell line undergoes precise DNA modifications that induce a complete gene knockout, allowing scientists to assess the downstream effects of ERBIN deficiency on cellular processes.

The key function of ERBIN Gene Knockout Cell Lines lies in their ability to simulate a range of biological conditions under controlled laboratory settings. ERBIN (Erbb2 interacting protein) is implicated in several critical cellular functions, including cell signaling, development, and oncogenesis. By utilizing these knockout lines, researchers can identify the impacts of ERBIN loss on processes such as cellular proliferation, differentiation, and apoptosis. This capability is invaluable in the context of cancer research, where understanding the role of specific genes in tumorigenesis can lead to new therapeutic strategies.

The scientific importance of these cell lines extends to both fundamental research and clinical applications; they serve as essential tools for drug discovery and the development of targeted therapies. The unique selling points of ERBIN Gene Knockout Cell Lines include their high specificity and the reproducibility of results, which are often not achievable with other methods such as RNA interference. Furthermore, these cell lines can be utilized across various types of human cell lines, enhancing their versatility in research.

For researchers and clinicians, the clear advantage of utilizing ERBIN Gene Knockout Cell Lines lies in their ability to provide profound insights into gene function and regulation, which could inform novel therapeutic avenues. As our understanding of gene-environment interactions improves, so too does the opportunity for advancing personalized medicine.

Our company, renowned for its expertise in developing innovative biological products, stands committed to providing high-quality genetic tools such as ERBIN Gene Knockout Cell Lines. We strive to support the scientific community in unlocking the complexities of gene function, ultimately contributing to advancements in health and disease management.

Please note that all services are for research use only. Not intended for any clinical use.

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