Gene: DES
Official Full Name: desminprovided by HGNC
Gene Summary: This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02079 | DES Knockout cell line (HeLa) | Human | DES | 1:3~1:6 | Negative | Online Inquiry |
KO02080 | DES Knockout cell line (HCT 116) | Human | DES | 1:2~1:4 | Negative | Online Inquiry |
DES Gene Knockout Cell Lines are specifically engineered cell lines in which the desmin (DES) gene has been disrupted, providing a crucial tool for researchers studying muscle biology and related diseases. These knockout cell lines function by eliminating the expression of desmin, a key intermediate filament protein that plays a significant role in maintaining muscle integrity and facilitating cellular signaling. Knockout models enable the direct observation of phenotypic changes associated with the loss of DES, giving researchers a clearer understanding of the protein's role in skeletal and cardiac muscle physiology.
The scientific importance of DES Gene Knockout Cell Lines cannot be overstated, as they are invaluable for investigating muscle disorders such as cardiomyopathies and muscular dystrophies that are linked to desmin mutations. In clinical research settings, these cell lines can be employed to assess the effects of potential therapeutic agents or to develop strategies for gene editing and replacement therapies. Furthermore, their application extends beyond basic research; they serve as platforms for drug testing and potentially in regenerative medicine applications.
What sets our DES Gene Knockout Cell Lines apart from alternative models is the precision of our gene-editing technologies and the stability of these cell lines, which have been confirmed through extensive validation studies. They are produced using stringent quality control measures to ensure consistency and performance in experimental conditions. By using our cell lines, researchers can save valuable time and resources while accessing a reliable system to dissect complex biological questions.
This product is immensely valuable to researchers and clinicians seeking to unravel the intricate mechanisms underlying muscle diseases and to develop novel therapeutic approaches. Our company prides itself on delivering high-quality biological products with unparalleled expertise, ensuring that our customers have access to the tools they need for groundbreaking research and clinical advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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