Gene: BCAR1
Official Full Name: BCAR1 scaffold protein, Cas family memberprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08781 | BCAR1 Knockout cell line (HeLa) | Human | BCAR1 | 1:3~1:6 | Negative | Online Inquiry |
KO08782 | BCAR1 Knockout cell line (HCT 116) | Human | BCAR1 | 1:2~1:4 | Negative | Online Inquiry |
KO08783 | BCAR1 Knockout cell line (HEK293) | Human | BCAR1 | 1:3~1:6 | Negative | Online Inquiry |
KO08784 | BCAR1 Knockout cell line (A549) | Human | BCAR1 | 1:3~1:4 | Negative | Online Inquiry |
BCAR1 Gene Knockout Cell Lines are specialized cellular models wherein the BCAR1 gene, implicated in breast cancer metastasis, has been genetically disrupted. These cell lines enable researchers to study the functional implications of BCAR1 deletion on various cellular processes, especially those associated with tumor progression, migration, and drug resistance. By allowing the precise manipulation of the BCAR1 gene, these cell lines serve as invaluable tools in dissecting the role of BCAR1 in cancer biology.
The primary function of these cell lines is to elucidate the biochemical pathways and cellular responses that are influenced by BCAR1. By utilizing CRISPR-Cas9 gene-editing technology, the knockout of the BCAR1 gene can trigger profound alterations in cell signaling pathways, thus allowing researchers to investigate downstream effects such as changes in cell adhesion, proliferation, and survival under therapeutic stress. This mechanistic insight is critical for understanding how the absence of BCAR1 may affect tumor behavior and drug response.
The scientific importance of BCAR1 Gene Knockout Cell Lines extends to both research and clinical applications, particularly in oncology. They facilitate comprehensive studies aimed at identifying potential therapeutic targets and biomarkers for breast cancer treatment. Furthermore, these cell lines can be employed in preclinical drug testing, aiding in the development of more effective therapeutic strategies while minimizing unwarranted side effects on normal cellular functions.
What sets our BCAR1 Gene Knockout Cell Lines apart from alternatives is their careful validation and characterization, ensuring reproducibility and reliability in experimental results. Each cell line comes with rigorous quality control data, giving researchers confidence in the data generated. Additionally, the gene-editing strategy employed provides a versatile platform to introduce further genetic modifications, thus expanding the scope of experimental design.
For researchers, clinicians, and pharmaceutical developers, investing in BCAR1 Gene Knockout Cell Lines is crucial for advancing our understanding of breast cancer mechanisms and therapeutic vulnerabilities. By utilizing these state-of-the-art models, users will not only accelerate their research but can also contribute to the evolution of cancer treatments.
Our company has a longstanding commitment to providing high-quality, innovative biological products, and our expertise in gene editing and cellular biology ensures that our BCAR1 Gene Knockout Cell Lines support cutting-edge research and clinical advancements in oncology.
Please note that all services are for research use only. Not intended for any clinical use.
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