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ADM2 Knockout Cell Lines

Gene: ADM2

Official Full Name: adrenomedullin 2provided by HGNC

Gene Summary: This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. [provided by RefSeq, Jul 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20660 ADM2 Knockout cell line (HCT 116) Human ADM2 1:2~1:4 Negative Online Inquiry

Background

ADM2 Gene Knockout Cell Lines are meticulously engineered cellular models designed to investigate the functional role of the ADM2 gene, specifically its involvement in various physiological and pathological processes. These cell lines are created using state-of-the-art CRISPR-Cas9 technology, which facilitates precise and targeted editing of the ADM2 gene, resulting in complete gene knockout. The absence of ADM2 expression allows researchers to elucidate its contributions to cell signaling pathways, metabolic regulation, and potential implications in disease states such as cancer, metabolic disorders, and cardiovascular conditions.

The primary mechanism of action involves the disruption of the gene's coding sequence, leading to a loss-of-function phenotype. This enables researchers to study the resultant biochemical changes and adaptations in cellular behavior, providing insights into the gene's role in health and disease. The ADM2 knockout models are pivotal in unraveling complex gene interactions and can significantly advance our understanding of gene function through comparative analyses with wild-type cells.

From a scientific perspective, these cell lines are invaluable for both fundamental research aiming to decode gene functions and translational studies exploring therapeutic interventions. They serve as a crucial tool for drug discovery and development, particularly in screening compounds that may modulate pathways affected by ADM2 deficiency.

What sets ADM2 Gene Knockout Cell Lines apart from alternative models is their high specificity and reliability, ensuring reproducible results that stem from well-characterized genetic modifications. Additionally, the adaptability of these cell lines for high-throughput applications enhances their utility in various experimental designs, making them a versatile asset in any laboratory's research arsenal.

For researchers and clinicians, the value of ADM2 Gene Knockout Cell Lines lies not only in their ability to generate relevant biological insights but also in their potential to contribute to the development of novel therapies targeting conditions linked to ADM2 dysregulation.

Our company prides itself on its commitment to pioneering genetic technologies and providing high-quality biological products that empower scientific discovery. With extensive expertise in cell line development and gene editing, we deliver cutting-edge solutions that address the needs of researchers and clinicians alike.

Please note that all services are for research use only. Not intended for any clinical use.

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