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ACP2 Knockout Cell Lines

Gene: ACP2

Official Full Name: acid phosphatase 2, lysosomalprovided by HGNC

Gene Summary: The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03007 ACP2 Knockout cell line (HeLa) Human ACP2 1:3~1:6 Negative Online Inquiry
KO03008 ACP2 Knockout cell line (HCT 116) Human ACP2 1:2~1:4 Negative Online Inquiry
KO03009 ACP2 Knockout cell line (HEK293) Human ACP2 1:3~1:6 Negative Online Inquiry
KO03010 ACP2 Knockout cell line (A549) Human ACP2 1:3~1:4 Negative Online Inquiry

Background

ACP2 Gene Knockout Cell Lines are genetically engineered cell lines in which the ACP2 gene has been inactivated, providing a powerful tool for researchers studying gene function and its implications in both normal physiology and disease states. The ACP2 gene encodes the enzyme lysosome-associated carboxypeptidase, which is involved in protein degradation and cellular metabolism. This targeted knockout allows for the examination of the gene's role in various cellular processes and pathologies, including lysosomal storage disorders.

The key function of ACP2 Gene Knockout Cell Lines lies in their ability to facilitate the investigation of the biological consequences of the absence of the ACP2 protein. Researchers can explore downstream effects on metabolic pathways, signaling networks, and cellular differentiation processes. By utilizing these knockout lines, scientists are equipped to better understand disease mechanisms and identify potential therapeutic targets, particularly in areas concerning neurodegenerative diseases and cancer, where lysosomal function can be compromised.

The scientific importance of ACP2 Gene Knockout Cell Lines is underscored by their application in both fundamental research and translational studies. They provide valuable insights into gene regulation, protein interactions, and the cellular responses to stress. These applications can lead to the development of novel therapeutic strategies, especially for conditions linked to lysosomal dysfunction.

Compared to alternative methods for studying gene function, such as RNA interference or CRISPR-based approaches with incomplete gene knockout, ACP2 Gene Knockout Cell Lines present a stable model with full gene inactivation. This ensures consistency and reproducibility in experiments, which is critical for reliable data collection.

For researchers and clinicians, the value of ACP2 Gene Knockout Cell Lines is evident in their potential to accelerate discoveries in the understanding of genetic contributions to various diseases. The ability to directly manipulate and observe the effects of gene loss on cellular behavior makes these cell lines an indispensable resource.

Our company specializes in producing high-quality cellular models that empower scientists to unlock the complexities of gene function in health and disease. With a commitment to innovation and precision in biological research tools, we aim to support the advancement of scientific knowledge and therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

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