PADI2 Knockout cell line (AC16)

Catalog Number: KOA11083

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Specifications

Product Information
Product Name	PADI2 Knockout cell line (AC16)
specification	1*10^6
Storage and transportation	Shipped on dry ice; Store in liquid nitrogen
Cell morphology	Fibroblast-like, adherent
Passage ratio	1：3-1：4
species	Human
Gene	PADI2
Gene ID	11240
Build method	Electroporation/Lentivirus
Mycoplasma testing	negative
Cultivation system	90% DMEM/F12+10% FBS
Parental Cell Line	AC16
Quality Control	Genotype: PADI2 Knockout cell line (AC16)>95% viability before freezing. All cells were tested and found to be free of bacterial, viruses,mycoplasma and other toxins.

Gene Information
Gene Official Full Name	peptidyl arginine deiminase 2provided by HGNC
Also known as	PAD2; PDI2; PAD-H19
Gene Description	This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
Expression	Biased expression in colon (RPKM 47.2), brain (RPKM 33.8) and 6 other tissues See more

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