OAS2 Knockout cell line (NCM460)

Catalog Number: KOA76195

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Specifications

Product Information
Product Name	OAS2 Knockout cell line (NCM460)
specification	1*10^6
Storage and transportation	Shipped on dry ice; Store in liquid nitrogen
Cell morphology	Epithelial-like, adheren
Passage ratio	1:2~1:3
species	Human
Gene	OAS2
Gene ID	4939
Build method	Electroporation/Lentivirus
Mycoplasma testing	negative
Cultivation system	90%RPMI-1640+10%FBS
Parental Cell Line	NCM460
Quality Control	Genotype: OAS2 Knockout cell line (NCM460)>95% viability before freezing. All cells were tested and found to be free of bacterial, viruses,mycoplasma and other toxins.

Gene Information
Gene Official Full Name	2'-5'-oligoadenylate synthetase 2provided by HGNC
Gene Description	This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression	Broad expression in spleen (RPKM 18.2), lymph node (RPKM 14.1) and 22 other tissues See more

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