Mammalian Cell-Free Protein Synthesis

While E. coli systems are high-yield, they cannot perform complex post-translational modifications. Our CHO platform provides therapeutic-grade glycosylation and proper disulfide bond formation, which are essential for the folding and biological activity of antibodies, cytokines, and membrane targets.

Yes. We specialize in the rapid production of full-length IgGs, scFvs, and bi-specific formats. By tuning the redox environment of the CHO lysate, we ensure correct assembly of multiple chains and proper N-glycosylation in the Fc region.

Our mammalian extracts contain endogenous microsomal structures (ER-derived vesicles). Membrane proteins are co-translationally inserted into these vesicles. For specific applications like SPR or NMR, we can also provide nanodisc-assisted synthesis.