CDKN1B Knockout cell line (A549)

Catalog Number: KO10430

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Specifications

Product Information
Product Name	CDKN1B Knockout cell line (A549)
specification	1*10^6
Storage and transportation	Dry ice preservation/T25 live cell transportation.
Cell morphology	Epithelioid, adherent cell
Passage ratio	1:3~1:4
species	Human
Gene	CDKN1B
Gene ID	1027
Build method	Electric rotation method / virus method
Mycoplasma testing	Negative
Cultivation system	90% F12K+10% FBS
Parental Cell Line	A549
Quality Control	Genotype: CDKN1B Knockout cell line (A549) >95% viability before freezing. All cells were tested and found to be free of bacterial, viruses,mycoplasma and other toxins.

Gene Information
Gene Official Full Name	cyclin dependent kinase inhibitor 1Bprovided by HGNC
Also known as	KIP1; MEN4; CDKN4; MEN1B; P27KIP1
Gene Description	This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
Expression	Ubiquitous expression in fat (RPKM 40.2), ovary (RPKM 35.6) and 25 other tissues See more

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