Gene: ZYX
Official Full Name: zyxinprovided by HGNC
Gene Summary: Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34450 | ZYX Knockout cell line (HeLa) | Human | ZYX | 1:3~1:6 | Negative | Online Inquiry |
KO34451 | ZYX Knockout cell line (HCT 116) | Human | ZYX | 1:2~1:4 | Negative | Online Inquiry |
KO34452 | ZYX Knockout cell line (HEK293) | Human | ZYX | 1:3~1:6 | Negative | Online Inquiry |
KO34453 | ZYX Knockout cell line (A549) | Human | ZYX | 1:3~1:4 | Negative | Online Inquiry |
ZYX Gene Knockout Cell Lines are specialized cell lines that have been genetically engineered to lack the ZYX gene, a critical component involved in various cellular processes, including cell adhesion, migration, and signaling pathways that influence developmental biology and disease progression. These cell lines are invaluable tools in molecular biology, enabling researchers to dissect gene function, investigate disease mechanisms, and evaluate potential therapeutic targets.
The primary function of ZYX Gene Knockout Cell Lines is to facilitate the study of the ZYX gene's role in cellular mechanisms. By observing the phenotype of these knockout cells compared to their wild-type counterparts, researchers can gain insights into the biological impacts of ZYX depletion. The mechanism underlying the functionality of these cell lines involves CRISPR/Cas9 technology or other gene-editing techniques that specifically target and disrupt the ZYX gene, ensuring precise and reproducible gene knockout.
Scientifically, the ZYX Gene Knockout Cell Lines are significant for basic research in cell biology, cancer research, and developmental studies. They are particularly useful for exploring the role of the ZYX gene in cancer progression and metastasis, thereby establishing potential links to therapeutic interventions. In clinical settings, these knockout cell lines offer a platform to screen for new drugs or identify vulnerabilities in cancer cells, paving the way for innovative treatment strategies.
One of the standout advantages of ZYX Gene Knockout Cell Lines over traditional models is their specificity and reproducibility. Unlike transient knockdown methods that give only temporary effects, these knockout cell lines provide a stable system for extended studies, thus yielding reliable and consistent data. Additionally, they can be easily used in various assays, including drug response studies, high-throughput screening, and mechanistic investigations, allowing researchers to generate robust conclusions.
For researchers and clinicians, the value of ZYX Gene Knockout Cell Lines lies in their ability to accelerate discoveries and contribute to a deeper understanding of cellular functions. By utilizing these specialized cell lines, professionals can explore pathways of interest with greater ease and reliability, ultimately translating findings into clinical applications.
Our company is dedicated to providing high-quality, genetically modified cell lines that adhere to the highest standards of research integrity, ensuring that our customers have the tools they need to make significant advancements in their scientific endeavors. With expertise in genetic engineering and a commitment to innovation, we empower researchers to push the boundaries of biological knowledge.
Please note that all services are for research use only. Not intended for any clinical use.
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