Gene: ZUP1
Official Full Name: zinc finger containing ubiquitin peptidase 1provided by HGNC
Gene Summary: This gene encodes a protein containing zinc finger motifs and a cysteine peptidase domain. The encoded protein functions as a K63-specific de-ubiquitinating enzyme that specifically cleaves long K63-linked polyubiquitin chains in the middle of a chain (i.e. "endo cleavage) rather than by removing the terminal ubiquitin from a chain. This enzyme is thought to be involved in the regulation of DNA repair by cleaving K63-linked ubiquitin chains at repair foci. This protein is related to proteases for the ubiquitin-like modifiers Ufm1 (ubiquitin fold modifier 1) and Atg8/Gabarapl2, but does not have any activity on these modifiers. [provided by RefSeq, Mar 2018]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27520 | ZUP1 Knockout cell line (HeLa) | Human | ZUP1 | 1:3~1:6 | Negative | Online Inquiry |
KO27521 | ZUP1 Knockout cell line (HCT 116) | Human | ZUP1 | 1:2~1:4 | Negative | Online Inquiry |
KO27522 | ZUP1 Knockout cell line (HEK293) | Human | ZUP1 | 1:3~1:6 | Negative | Online Inquiry |
KO27523 | ZUP1 Knockout cell line (A549) | Human | ZUP1 | 1:3~1:4 | Negative | Online Inquiry |
ZUP1 Gene Knockout Cell Lines represent a pioneering advancement in the field of genetic research and biotechnology, specifically designed to facilitate the study of the ZUP1 gene's role in cellular processes. These cell lines have been meticulously engineered using CRISPR-Cas9 technology to induce targeted mutations, resulting in the complete knockout of the ZUP1 gene. This process allows researchers to analyze the biological implications of ZUP1 deficiency in a controlled environment, elucidating its impact on various physiological pathways and cellular functions.
The primary mechanism underpinning the utility of ZUP1 Gene Knockout Cell Lines lies in their ability to provide a model for studying gene function, signaling pathways, and disease mechanisms. By specifically disrupting the ZUP1 gene, these cell lines enable researchers to investigate phenotypic changes, cellular responses, and potential compensatory mechanisms that may arise as a result of gene loss. Such insights are critical for understanding the gene's role in health and disease, paving the way for potential therapeutic interventions.
Scientific importance extends beyond basic research into various clinical settings, especially in the realm of drug discovery and personalized medicine. ZUP1 knockout models can significantly aid in screening compounds that target pathways influenced by ZUP1, ultimately providing a valuable framework for understanding how therapies might modify gene expression and its associated effects.
Compared to traditional gene knockout methods, ZUP1 Gene Knockout Cell Lines offer enhanced specificity and efficiency, minimizing off-target effects often seen with older techniques. This innovation streamlines the generation of knockout models, significantly reducing the time and resources needed for experimental validation.
For researchers and clinicians, ZUP1 Gene Knockout Cell Lines present a unique opportunity to explore uncharted territories in genomics and transcriptomics. The precise nature of these models is integral for advancing our understanding of genetic contributions to complex diseases, thus offering a compelling advantage over other experimental systems.
Our company brings years of expertise in the field of genetic engineering, providing high-quality biological products, including ZUP1 Gene Knockout Cell Lines. We are committed to supporting the research community with innovative solutions and unparalleled customer service, ensuring researchers have the tools they need to advance scientific knowledge and improve patient outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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