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ZNF384 Knockout Cell Lines

Gene: ZNF384

Official Full Name: zinc finger protein 384provided by HGNC

Gene Summary: This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12273 ZNF384 Knockout cell line (HeLa) Human ZNF384 1:3~1:6 Negative Online Inquiry
KO12274 ZNF384 Knockout cell line (HCT 116) Human ZNF384 1:2~1:4 Negative Online Inquiry
KO12275 ZNF384 Knockout cell line (HEK293) Human ZNF384 1:3~1:6 Negative Online Inquiry
KO12276 ZNF384 Knockout cell line (A549) Human ZNF384 1:3~1:4 Negative Online Inquiry

Background

ZNF384 Gene Knockout Cell Lines are a specialized biological tool designed to facilitate the functional characterization of the ZNF384 gene and its associated pathways in cellular systems. This product consists of cell lines in which the ZNF384 gene has been strategically inactivated through established gene editing technologies, such as CRISPR-Cas9. By disabling this gene, researchers can delve into its role in cellular processes, including differentiation, proliferation, and response to various stimuli.

The key function of these knockout cell lines is to provide a controlled environment for studying the biological roles of ZNF384 in health and disease. The absence of ZNF384 allows for the observation of downstream effects on gene expression and cellular behavior, enabling researchers to better understand its involvement in critical pathways, including those related to hematopoiesis and tumorigenesis. This is particularly valuable in the context of diseases such as leukemia, where ZNF384 mutations have been implicated.

Scientifically, ZNF384 gene knockout cell lines have significant applications in both research and clinical settings. They aid in the discovery of novel therapeutic targets and the evaluation of drug responses, making them an essential resource in the fields of cancer research, genetic disorders, and regenerative medicine. Compared to alternatives, such as traditional siRNA methods or wild-type cell lines, these knockout cell lines provide a more definitive assessment of gene function, eliminating background interference from ZNF384 expression.

The intrinsic value of ZNF384 Gene Knockout Cell Lines lies in their ability to enhance the precision of experimental results and ease the exploration of complex biological mechanisms. Researchers and clinicians gain the advantage of working with an established model that reflects the gene's absence, paving the way for breakthroughs in understanding gene function, identifying therapeutic interventions, and advancing personalized medicine.

As a leader in innovative biological solutions, our company stands out with its commitment to quality and excellence. We focus on delivering cutting-edge research tools that empower scientists and enhance the efficiency of their research endeavors. The ZNF384 Gene Knockout Cell Lines underscore our dedication to supporting the scientific community in unlocking new insights into genetic regulation and its implications in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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