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ZNF280B Knockout Cell Lines

Gene: ZNF280B

Official Full Name: zinc finger protein 280Bprovided by HGNC

Gene Summary: The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25525 ZNF280B Knockout cell line (HCT 116) Human ZNF280B 1:2~1:4 Negative Online Inquiry
KO25526 ZNF280B Knockout cell line (HEK293) Human ZNF280B 1:3~1:6 Negative Online Inquiry
KO25527 ZNF280B Knockout cell line (A549) Human ZNF280B 1:3~1:4 Negative Online Inquiry

Background

ZNF280B Gene Knockout Cell Lines are genetically engineered cellular models designed to silence the expression of the ZNF280B gene, which plays a crucial role in various biological processes, including cellular proliferation, differentiation, and apoptosis. This knockout technology utilizes CRISPR/Cas9 gene editing, enabling precise and efficient alteration of the target genome, thereby allowing researchers to study the functional consequences of ZNF280B loss in a controlled environment.

The key functions of these knockout cell lines arise from their ability to elucidate the role of ZNF280B in gene regulation and its involvement in cancer pathways and other diseases. By removing the expression of this zinc finger protein, researchers can investigate its contribution to cellular mechanisms such as gene transcription, signal transduction, and developmental processes. This deepened understanding aids in the exploration of new therapeutics and provides insights into the etiology of various conditions linked to aberrant ZNF280B function.

The scientific importance of ZNF280B Gene Knockout Cell Lines cannot be overstated. In both research and clinical settings, these models serve as pivotal tools for drug discovery, validation of gene-targeting therapies, and the development of innovative clinical applications aimed at conditions such as cancer and genetic disorders. They help bridge the gap between basic research and clinical translation.

Compared to traditional cell lines that may express wild-type ZNF280B, our knockout cell lines offer the unparalleled advantage of creating a more accurate model for studying specific gene functions and regulatory mechanisms. The specificity and efficiency associated with our CRISPR/Cas9 methodology also yield higher success rates, reducing the time and resources required for functional analysis.

For researchers and clinicians striving to harness gene editing technologies in a robust manner, ZNF280B Gene Knockout Cell Lines present a unique opportunity to advance their work. These models not only empower studies in gene function but also facilitate the quest for novel therapeutic approaches.

Our company is committed to excellence in producing high-quality biological products, leveraging cutting-edge technologies and a deep understanding of genetic engineering. We pride ourselves on being a leading provider in the field, ensuring that researchers have access to the tools necessary to unlock new scientific discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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