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ZNF217 Knockout Cell Lines

Gene: ZNF217

Official Full Name: zinc finger protein 217provided by HGNC

Gene Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in mitochondrion and nuclear speck. Part of histone deacetylase complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01460 ZNF217 Knockout cell line(MDA-MB-231) Human ZNF217 1:2~1:4 Negative Online Inquiry
KO12340 ZNF217 Knockout cell line (HeLa) Human ZNF217 1:3~1:6 Negative Online Inquiry
KO12341 ZNF217 Knockout cell line (HCT 116) Human ZNF217 1:2~1:4 Negative Online Inquiry
KO12342 ZNF217 Knockout cell line (HEK293) Human ZNF217 1:3~1:6 Negative Online Inquiry
KO12343 ZNF217 Knockout cell line (A549) Human ZNF217 1:3~1:4 Negative Online Inquiry

Background

ZNF217 Gene Knockout Cell Lines are advanced genetic models specifically designed to facilitate the study of the ZNF217 gene's role in various biological processes. The ZNF217 gene is known to function as a transcription factor, implicated in the regulation of gene expression and associated with numerous oncogenic pathways. By utilizing CRISPR-Cas9 gene editing technology, these knockout cell lines allow for the precise deletion of ZNF217, enabling researchers to observe the resultant phenotypic changes and gene interactions.

The primary mechanism of these cell lines hinges on the targeted disruption of the ZNF217 gene, effectively mimicking loss-of-function mutations commonly observed in cancer. This enables a deeper understanding of ZNF217's contribution to cellular proliferation, apoptosis, and differentiation. Researchers can employ these lines in functional assays to elucidate pathways related to tumorigenesis and metastasis, ultimately contributing valuable insights into cancer biology.

The scientific importance of ZNF217 Gene Knockout Cell Lines is underscored by their applicability in both fundamental research and clinical settings. They serve as crucial models for drug screening, biomarker discovery, and the development of novel therapeutic strategies tailored for cancers associated with ZNF217 dysregulation.

Compared to traditional cell lines, which often retain a fully functional ZNF217 gene, these knockout lines offer the unique advantage of circumventing the limitations imposed by residual gene activity, thereby providing clearer insights into gene functions and interactions. Additionally, researchers benefit from accelerated experimental timelines through simplified validation processes.

For researchers, clinicians, and biotechnological entities focused on advancing cancer research and therapeutic developments, ZNF217 Gene Knockout Cell Lines represent an invaluable tool in the quest to decode the complexities of gene function. Our company is committed to providing high-quality biological products backed by extensive expertise in gene editing technology, ensuring that our offerings continually meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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