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ZNF214 Knockout Cell Lines

Gene: ZNF214

Official Full Name: zinc finger protein 214provided by HGNC

Gene Summary: This gene is expressed predominantly in the testis and encodes a zinc finger protein that contains an N-terminal kruppel-associated box A (KRABA) domain and twelve zinc finger domains. This gene is located within one of three regions on chromosome 11p15 associated with Beckwith-Wiedemann syndrome, called Beckwith-Wiedemann syndrome chromosome region-2 (BWSCR2), and is thought to play a role in the etiology of this disease. [provided by RefSeq, Aug 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34510 ZNF214 Knockout cell line (HeLa) Human ZNF214 1:3~1:6 Negative Online Inquiry
KO34511 ZNF214 Knockout cell line (HCT 116) Human ZNF214 1:2~1:4 Negative Online Inquiry
KO34512 ZNF214 Knockout cell line (HEK293) Human ZNF214 1:3~1:6 Negative Online Inquiry

Background

ZNF214 Gene Knockout Cell Lines are genetically engineered cell lines designed to silence the ZNF214 gene, which encodes a zinc-finger transcription factor implicated in various biological processes, including cell differentiation, development, and oncogenic pathways. These knockout cell lines serve as crucial tools for researchers investigating the functional roles of ZNF214 in cellular mechanisms, providing insights into gene regulation and its contributions to disease pathways.

The primary function of ZNF214 Gene Knockout Cell Lines lies in the elimination of ZNF214 expression, enabling the study of cellular phenotypes associated with its absence. Through techniques such as CRISPR-Cas9 or TALEN, scientists can create specific deletions in the ZNF214 gene, leading to altered gene expression profiles and cellular behaviors. This functional alteration allows researchers to elucidate ZNF214's involvement in processes such as apoptosis, proliferation, and stem cell differentiation, thereby deepening the understanding of the pathological roles the gene may play in conditions like cancer and developmental disorders.

The scientific importance of these cell lines extends into both research and clinical applications. In the laboratory, they provide a platform for high-throughput screening of therapeutic agents that target ZNF214-related pathways. Clinically, understanding ZNF214 function could pave the way for novel treatment strategies and diagnostic markers in oncology.

What sets ZNF214 Gene Knockout Cell Lines apart from alternative models is their specificity and reliability. By directly knocking out the ZNF214 gene, researchers can achieve more precise and reproducible results than those obtained from transient knockdown methods, such as siRNA, which may produce off-target effects or temporary alterations in gene expression.

For researchers and clinicians alike, the value of ZNF214 Gene Knockout Cell Lines lies in their ability to facilitate comprehensive studies of gene function in a controlled environment, ultimately advancing the understanding of disease mechanisms and potential therapeutic interventions. Our company specializes in delivering high-quality, validated genetic products, ensuring that our offerings meet rigorous scientific standards to support innovative research in genetics and molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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