Home / ZFP36L1 Knockout Cell Lines

ZFP36L1 Knockout Cell Lines

Gene: ZFP36L1

Official Full Name: ZFP36 ring finger protein like 1provided by HGNC

Gene Summary: This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38781 ZFP36L1 Knockout cell line (HeLa) Human ZFP36L1 1:3~1:6 Negative Online Inquiry
KO38782 ZFP36L1 Knockout cell line (HCT 116) Human ZFP36L1 1:2~1:4 Negative Online Inquiry
KO38783 ZFP36L1 Knockout cell line (HEK293) Human ZFP36L1 1:3~1:6 Negative Online Inquiry
KO38784 ZFP36L1 Knockout cell line (A549) Human ZFP36L1 1:3~1:4 Negative Online Inquiry

Background

ZFP36L1 Gene Knockout Cell Lines are sophisticated cellular models that have been engineered to lack the ZFP36L1 gene, a pivotal regulator in post-transcriptional gene expression. This product serves as an indispensable tool for researchers investigating the riboregulation mechanisms that control mRNA stability and degradation. The targeted knockout of the ZFP36L1 gene allows scientists to discern the impacts of diminished ZFP36L1 activity on various cellular processes, including stress responses, proliferation, and differentiation, thus offering insight into gene regulatory networks.

The primary function of ZFP36L1 is to bind to AU-rich elements within the 3’ untranslated regions of target mRNAs, promoting their decay and thereby controlling the levels of protein output within the cell. By utilizing the ZFP36L1 Gene Knockout Cell Lines, researchers can effectively dissect the consequences of this regulatory pathway on critical biological functions, facilitating a deeper understanding of disease mechanisms, especially those related to inflammation and cancer.

In terms of scientific importance, these cell lines hold significant promise for applications in both fundamental research and translational studies. They offer unique advantages in exploring therapeutic strategies that target mRNA stability. By providing a controlled environment where ZFP36L1 is specifically ablated, researchers can more accurately assess the molecular responses to potential interventions, making these cell lines particularly valuable for drug discovery and development.

Comparatively, while other gene knockout models exist, ZFP36L1 Gene Knockout Cell Lines stand out due to their specificity and the pivotal role of ZFP36L1 in various diseases. This specificity allows for more reliable and reproducible results, essential for validating novel research hypotheses.

Ultimately, the ZFP36L1 Gene Knockout Cell Lines are a crucial asset for researchers and clinicians alike, facilitating groundbreaking discoveries and enhancing our understanding of mRNA regulation in health and disease. Our company prides itself on leading the development of high-quality biological products, underpinned by the expertise of our dedicated research teams, ensuring that our offerings meet the highest standards of scientific rigor.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.