Gene: YWHAH
Official Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein etaprovided by HGNC
Gene Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08493 | YWHAH Knockout cell line (HeLa) | Human | YWHAH | 1:3~1:6 | Negative | Online Inquiry |
KO08494 | YWHAH Knockout cell line (HCT 116) | Human | YWHAH | 1:2~1:4 | Negative | Online Inquiry |
KO08495 | YWHAH Knockout cell line (HEK293) | Human | YWHAH | 1:3~1:6 | Negative | Online Inquiry |
KO08496 | YWHAH Knockout cell line (A549) | Human | YWHAH | 1:3~1:4 | Negative | Online Inquiry |
YWHAH Gene Knockout Cell Lines are specialized cell lines that have been genetically engineered to lack the expression of the YWHAH gene, which encodes the 14-3-3 protein family member. These knockout models are invaluable tools for researchers aiming to investigate the multifaceted roles of YWHAH in cellular processes such as signal transduction, cell cycle regulation, and apoptosis. By studying these knockouts, scientists can elucidate the pathways and mechanisms through which YWHAH exerts its influence on cell behavior, thereby providing insights into its involvement in various diseases, including cancer and neurodegenerative disorders.
The YWHAH gene knockout is achieved through advanced CRISPR/Cas9 technology, allowing for precise modifications at the genomic level. This high specificity minimizes off-target effects and ensures the integrity of adjacent genes, thus providing a reliable model for downstream experiments. In research settings, these cell lines can be used to assess the impact of YWHAH deletion on cellular signaling pathways, drug response, and stress tolerance, facilitating the discovery of new therapeutic targets and biomarkers.
In clinical applications, the insights gained from YWHAH gene knockout studies have the potential to lead to novel treatment strategies and diagnostic tools. Unlike many alternatives that may interfere with multiple pathways or lack clarity in results, YWHAH knockout cell lines afford researchers a direct observation of the resultant phenotypic changes, making them a powerful choice for those working in gene regulation and related fields.
Researchers and clinicians will find value in these cell lines, not only for their specificity and reliability but also for the depth of understanding they encourage regarding the YWHAH gene. Our company prides itself on delivering high-quality genetic models with meticulous attention to detail and the latest in gene-editing technologies, ensuring that our offerings meet the rigorous demands of modern biological research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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