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YME1L1 Knockout Cell Lines

Gene: YME1L1

Official Full Name: YME1 like 1 ATPaseprovided by HGNC

Gene Summary: The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00548 YME1L1 Knockout cell line (HEK293) Human YME1L1 1:3~1:6 Negative Online Inquiry
KO09750 YME1L1 Knockout cell line (HeLa) Human YME1L1 1:3~1:6 Negative Online Inquiry
KO09751 YME1L1 Knockout cell line (HCT 116) Human YME1L1 1:2~1:4 Negative Online Inquiry

Background

YME1L1 Gene Knockout Cell Lines represent a significant advancement in the study of mitochondrial dynamics and cellular stress responses. These cell lines have been meticulously engineered to lack the YME1L1 gene, which encodes a mitochondrial AAA+ ATPase involved in protein degradation and mitochondrial homeostasis. By removing this gene, researchers can create a controlled environment to evaluate the multifaceted roles of YME1L1 in mitochondrial function, apoptosis, and the cellular response to oxidative stress.

The primary mechanism of these knockout cell lines facilitates the investigation of numerous key biological functions, including mitochondrial morphology, mitochondrial DNA maintenance, and the regulation of mitophagy—critical for cellular health. By utilizing these cell lines, scientists can elucidate the underlying mechanisms of various mitochondrial pathologies and explore potential therapeutic interventions.

In both research and clinical settings, the YME1L1 Gene Knockout Cell Lines serve as an invaluable resource. They provide insight into mitochondrial diseases, neurodegenerative conditions, and metabolic disorders, contributing to the broader understanding of cellular physiology and pathology. These models can also be employed in drug discovery and development, enabling the identification and validation of therapeutic targets and compounds.

Compared to traditional cell lines, YME1L1 Gene Knockout Cell Lines offer the advantage of specificity and reproducibility, allowing researchers to delineate the effects of YME1L1 depletion more accurately. This targeted approach is crucial for making informed decisions regarding mitochondrial research and potential clinical applications.

For researchers and clinicians seeking to expand their understanding of mitochondrial roles in health and disease, the YME1L1 Gene Knockout Cell Lines offer unique insights and an innovative tool for advancing scientific knowledge. With our company's established expertise in genetic engineering and commitment to high-quality biological products, we provide scientists with reliable, cutting-edge tools essential for impactful research.

Please note that all services are for research use only. Not intended for any clinical use.

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