Gene: YAP1
Official Full Name: Yes1 associated transcriptional regulatorprovided by HGNC
Gene Summary: This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08619 | YAP1 Knockout cell line (HeLa) | Human | YAP1 | 1:3~1:6 | Negative | Online Inquiry |
KO08620 | YAP1 Knockout cell line (HCT 116) | Human | YAP1 | 1:2~1:4 | Negative | Online Inquiry |
KO08621 | YAP1 Knockout cell line (HEK293) | Human | YAP1 | 1:3~1:6 | Negative | Online Inquiry |
KO08622 | YAP1 Knockout cell line (A549) | Human | YAP1 | 1:3~1:4 | Negative | Online Inquiry |
YAP1 Gene Knockout Cell Lines are highly specialized cellular models engineered for precise studies into the role of the Yes-associated protein 1 (YAP1) gene, a critical regulator in the Hippo signaling pathway. These cell lines are generated through advanced CRISPR/Cas9 technology, allowing for the complete knockout of the YAP1 gene, thereby enabling researchers to investigate the downstream effects of its loss on cellular processes such as proliferation, apoptosis, and tissue regeneration.
The key mechanism behind these cell lines lies in their ability to provide a controlled environment to study the YAP1 signaling pathway's implications in various biological contexts, including cancer progression, development, and stem cell differentiation. By observing the phenotypic and molecular changes that occur in YAP1-deficient cells, researchers can gain crucial insights into the pathways that influence cellular behavior and tumorigenesis.
The scientific importance of YAP1 Gene Knockout Cell Lines extends into both basic and applied research. In clinical settings, understanding the role of YAP1 provides a pathway to identify potential therapeutic targets for conditions associated with dysregulated signaling pathways, such as liver cancer and heart disease. This product serves as a valuable tool for drug discovery, biomarker identification, and elucidation of cancer biology.
What sets these knockout cell lines apart from alternatives is their high specificity and reproducibility, alongside an easy integration into existing experimental frameworks, significantly reducing the time and resources needed to develop knockout models from scratch. This ensures researchers can focus on obtaining results rather than spending extensive time on the development phase.
For researchers and clinicians alike, YAP1 Gene Knockout Cell Lines represent an invaluable asset, enabling targeted investigations into one of the most studied oncogenic pathways. Our commitment to precision in genetic engineering and a robust support framework empowers our users to push boundaries in their research effectively. At [Your Company Name], we leverage cutting-edge technologies and profound expertise to provide high-quality biological products that advance scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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