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XPO4 Knockout Cell Lines

Gene: XPO4

Official Full Name: exportin 4provided by HGNC

Gene Summary: XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12550 XPO4 Knockout cell line (HeLa) Human XPO4 1:3~1:6 Negative Online Inquiry
KO12551 XPO4 Knockout cell line (HCT 116) Human XPO4 1:2~1:4 Negative Online Inquiry
KO12552 XPO4 Knockout cell line (HEK293) Human XPO4 1:3~1:6 Negative Online Inquiry
KO12553 XPO4 Knockout cell line (A549) Human XPO4 1:3~1:4 Negative Online Inquiry

Background

XPO4 Gene Knockout Cell Lines are specialized cellular models in which the XPO4 gene, responsible for exporting certain proteins from the nucleus to the cytoplasm, has been precisely knocked out using advanced gene-editing technologies like CRISPR-Cas9. These cell lines provide researchers with a unique platform to study the functional role of XPO4 in various cellular processes, including gene expression regulation, cellular signaling, and the response to stressors. By facilitating the retention of nuclear proteins, these knockout models enable a deeper investigation into pathways traditionally obscured by typical gene expression.

The primary function of XPO4 is to mediate the nuclear export of proteins, particularly those featuring a leucine-rich nuclear export signal. In research and clinical settings, understanding the consequences of disrupted XPO4 function can unravel significant insights related to cancer progression, viral propagation, and neurodegenerative diseases. The ability to manipulate XPO4 expression through knockout models empowers scientists to dissect molecular interactions and therapeutically target the pathways implicated in these conditions.

What sets our XPO4 Gene Knockout Cell Lines apart is their robust characterization and validation against control lines, ensuring researchers access reliable and reproducible systems. These cell lines are further optimized for high-throughput screening, allowing for efficient experimentation and data acquisition. While traditional methods of studying protein export mechanisms can be cumbersome and time-intensive, our knockout lines streamline this process, offering unparalleled convenience and specificity.

For researchers and clinicians engaged in the pursuit of groundbreaking discoveries, the XPO4 Gene Knockout Cell Lines represent an invaluable tool for innovative study. With our company’s commitment to excellence and a strong background in developing scientifically validated models, these products are designed to support advancements in therapeutic research and health applications. Our expertise in biological product development ensures that researchers receive high-quality tools essential for driving forward their investigations.

Please note that all services are for research use only. Not intended for any clinical use.

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