Gene: WRNIP1
Official Full Name: WRN helicase interacting protein 1provided by HGNC
Gene Summary: Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20924 | WRNIP1 Knockout cell line (HeLa) | Human | WRNIP1 | 1:3~1:6 | Negative | Online Inquiry |
KO20925 | WRNIP1 Knockout cell line (HCT 116) | Human | WRNIP1 | 1:2~1:4 | Negative | Online Inquiry |
KO20926 | WRNIP1 Knockout cell line (HEK293) | Human | WRNIP1 | 1:3~1:6 | Negative | Online Inquiry |
KO20927 | WRNIP1 Knockout cell line (A549) | Human | WRNIP1 | 1:3~1:4 | Negative | Online Inquiry |
WRNIP1 Gene Knockout Cell Lines are engineered cellular models that facilitate the study of WRNIP1 (Werner's syndrome protein interacting protein 1), a critical gene implicated in DNA repair and response to cellular stress. By genetically disrupting the WRNIP1 gene, these knockout cell lines allow researchers to investigate the physiological and biochemical consequences of WRNIP1 deficiency, significantly advancing our understanding of genomic stability and cancer biology.
These cell lines possess a unique mechanism of action that provides a controlled environment for the assessment of cell viability, proliferation, and DNA damage response pathways. By analyzing the functional disruption of WRNIP1, researchers can elucidate its role in various physiological processes, including telomere maintenance, DNA repair mechanisms, and replication stress responses, which are vital for maintaining cellular integrity and preventing tumorigenesis.
The scientific importance of WRNIP1 Gene Knockout Cell Lines extends to numerous research and clinical applications, notably in cancer research, aging studies, and the development of novel therapeutics targeting DNA repair pathways. The characterization of these cell lines will contribute to the foundational knowledge necessary for constructing targeted interventions or identifying potential biomarkers.
What sets WRNIP1 Gene Knockout Cell Lines apart from conventional cell models is their specificity and precision in modeling WRNIP1-mediated effects under standardized experimental conditions. This specificity ensures reproducibility, which is crucial for advancing research with robust datasets.
For researchers and clinicians focused on cancer biology and genomic stability, the value of these knockout cell lines is paramount, as they not only streamline experimental design but also enhance the potential for significant scientific discoveries. Their use can help clarify the role of WRNIP1 in disease processes, potentially leading to breakthroughs in personalized medicine.
As a leader in the field of genetic engineering and biological product development, our company is dedicated to providing high-quality, customizable cell line products that empower researchers to push the boundaries of scientific inquiry, enhancing innovation and improving therapeutic outcomes in healthcare.
Please note that all services are for research use only. Not intended for any clinical use.
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