Gene: WNK4
Official Full Name: WNK lysine deficient protein kinase 4provided by HGNC
Gene Summary: This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO12583 | WNK4 Knockout cell line (HCT 116) | Human | WNK4 | 1:2~1:4 | Negative | Online Inquiry |
KO12584 | WNK4 Knockout cell line (HEK293) | Human | WNK4 | 1:3~1:6 | Negative | Online Inquiry |
WNK4 Gene Knockout Cell Lines represent a significant advancement in genetic research, serving as invaluable tools for elucidating the biological functions of the WNK4 gene, which is implicated in regulating blood pressure and cellular ion transport. These cell lines are engineered using CRISPR-Cas9 technology to create precise deletions in the WNK4 gene, allowing researchers to study the resultant phenotypic changes and understand the gene's role in various physiological and pathological conditions.
The key function of WNK4 Gene Knockout Cell Lines lies in their ability to provide a modeled system that mimics the loss-of-function scenarios of WNK4, thereby facilitating the investigation of altered signaling pathways, cellular homeostasis, and ion channel function. Researchers can utilize these cell lines to explore mechanisms linked to hypertension and renal function, contributing to the broader understanding of cardiovascular diseases and metabolic syndromes.
From a scientific perspective, the applications of WNK4 Gene Knockout Cell Lines in both basic and applied research are profound. They serve as essential tools for drug discovery and development, enabling the screening of therapeutic compounds aimed at modulating WNK4-related pathways. In clinical settings, these models can aid in identifying potential biomarkers for disease predisposition and therapy response, thus contributing to personalized medicine approaches.
Compared to alternative models, such as conventional knockdown strategies or wild-type cell lines, WNK4 Gene Knockout Cell Lines provide a more comprehensive understanding due to their ability to offer complete gene disruptions rather than partial effects. This results in clearer interpretations of functional studies and drug responses, making them a superior choice for researchers focused on elucidating the critical roles of the WNK4 gene.
The value of WNK4 Gene Knockout Cell Lines extends to researchers and clinicians alike, offering a robust platform for innovative studies that promise to advance our understanding of genetic influences on health and disease. By integrating these knockout cell lines into their research, users can expect to accelerate the discovery process and enhance the quality of their findings.
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Please note that all services are for research use only. Not intended for any clinical use.
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