Gene: WNK3
Official Full Name: WNK lysine deficient protein kinase 3provided by HGNC
Gene Summary: This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO12585 | WNK3 Knockout cell line (HEK293) | Human | WNK3 | 1:3~1:6 | Negative | Online Inquiry |
WNK3 Gene Knockout Cell Lines are expertly engineered cellular models designed to facilitate the analysis of the WNK3 (With No K) gene and its associated signaling pathways. This product provides researchers with specialized cell lines in which the WNK3 gene has been inactivated, allowing for detailed exploration of its functions and contributions to various physiological and pathological processes.
The key function of WNK3 Gene Knockout Cell Lines lies in their ability to mimic the loss-of-function scenarios observed in genetic studies. Researchers utilize these models to investigate the role of WNK3 in cellular signal transduction, particularly in the context of ion transport and blood pressure regulation. The mechanisms at play include the modulation of downstream kinases and transporters, which are pivotal in maintaining electrolyte homeostasis. Through the use of these knockout cell lines, scientists can elucidate the gene's involvement in diseases such as hypertension and other cardiovascular disorders.
The scientific significance of WNK3 Gene Knockout Cell Lines extends into both research and clinical settings, serving as vital tools in drug discovery, basic biology, and therapeutic development. Understanding the implications of WNK3 deletion can inform potential interventions for conditions stemming from its dysregulation.
What sets WNK3 Gene Knockout Cell Lines apart from alternative models is their specificity and reliability, providing a reproducible system for investigating the unique biological roles of WNK3. Their adaptability for various experimental conditions adds to their appeal, allowing for integration into a host of research paradigms.
For researchers and clinicians seeking to advance their work on ion regulation and associated disorders, these cell lines offer unparalleled value. They not only save time and resources but also enhance experimental precision, making them a compelling choice for anyone studying the complex interactions of ion transport pathways.
Our company is dedicated to providing high-quality biological products rooted in scientific excellence, with a specialized portfolio designed to empower researchers in pushing the boundaries of knowledge in genetics and cell biology.
Please note that all services are for research use only. Not intended for any clinical use.
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