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WLS Knockout Cell Lines

Gene: WLS

Official Full Name: Wnt ligand secretion mediatorprovided by HGNC

Gene Summary: Enables Wnt-protein binding activity and identical protein binding activity. Involved in positive regulation of cell communication and protein transport. Located in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum membrane. Implicated in Zaki syndrome. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02504 WLS Knockout cell line (HeLa) Human WLS 1:3~1:6 Negative Online Inquiry
KO02505 WLS Knockout cell line (HCT 116) Human WLS 1:2~1:4 Negative Online Inquiry
KO02506 WLS Knockout cell line (HEK293) Human WLS 1:3~1:6 Negative Online Inquiry
KO02507 WLS Knockout cell line (A549) Human WLS 1:3~1:4 Negative Online Inquiry

Background

WLS Gene Knockout Cell Lines are genetically engineered cell models specifically developed to lack the expression of the WLS gene, which plays a crucial role in the Wnt signaling pathway. This innovative product enables researchers to study the functional consequences of WLS deficiency in various biological processes, including cell proliferation, differentiation, and tissue homeostasis. The knockout mechanism typically utilizes CRISPR-Cas9 technology, allowing precise edits to the genomic sequence, ensuring a reliable model that offers a high level of specificity in experimentation.

The primary function of WLS Gene Knockout Cell Lines lies in their application for dissecting the complexities of Wnt signaling, which is vital for numerous cellular functions and development phases. These cell lines are instrumental in elucidating the role that WLS plays in cancer biology, neurodevelopmental disorders, and regenerative medicine, thus providing a valuable tool for both basic and translational research. Furthermore, they can be utilized in drug discovery and testing, enabling the identification of potential therapeutic targets.

Compared to traditional models, such as wild-type or knock-in variants, WLS Gene Knockout Cell Lines present significant advantages, including higher reproducibility of results and the ability to study the effects of gene loss in a controlled environment. The specificity of this product minimizes off-target effects commonly associated with other knockout strategies, ensuring that data derived from experiments are both reliable and applicable to real-world scenarios.

Researchers and clinicians can leverage the unique features of WLS Gene Knockout Cell Lines to gain insights into cellular mechanisms, paving the way for novel therapeutic approaches. Our product not only accelerates scientific discovery but also enhances experimental efficacy, making it an indispensable resource in modern biological research.

Our company specializes in providing high-quality, genetically modified cell lines, backed by a team of experts committed to supporting researchers in their scientific endeavors. With our extensive experience in genetic engineering and a robust quality assurance process, we are dedicated to delivering products that empower the scientific community and foster breakthroughs in understanding complex biological systems.

Please note that all services are for research use only. Not intended for any clinical use.

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