Gene: WDR48
Official Full Name: WD repeat domain 48provided by HGNC
Gene Summary: The protein encoded by this gene has been shown to interact with ubiquitin specific peptidase 1 (USP1), activating the deubiquitinating activity of USP1 and allowing it to remove the ubiquitin moiety from monoubiquitinated FANCD2. FANCD2 is ubiquitinated in response to DNA damage. [provided by RefSeq, Sep 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20618 | WDR48 Knockout cell line (HeLa) | Human | WDR48 | 1:3~1:6 | Negative | Online Inquiry |
KO20619 | WDR48 Knockout cell line (HCT 116) | Human | WDR48 | 1:2~1:4 | Negative | Online Inquiry |
KO20620 | WDR48 Knockout cell line (HEK293) | Human | WDR48 | 1:3~1:6 | Negative | Online Inquiry |
KO20621 | WDR48 Knockout cell line (A549) | Human | WDR48 | 1:3~1:4 | Negative | Online Inquiry |
WDR48 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to facilitate the study of the WDR48 gene, known for its role in regulating various cellular processes, including cytokine signaling, DNA repair, and cellular response to stress. By using CRISPR-Cas9 technology, these cell lines have been precisely edited to eliminate WDR48 expression, allowing researchers to observe the phenotypic and molecular consequences of this knockout.
The primary function of WDR48 Gene Knockout Cell Lines lies in their capacity to serve as a robust platform for investigating the biological roles of the WDR48 protein. The absence of WDR48 protein provides insights into altered cellular behaviors, including changes in proliferation, differentiation, and apoptosis pathways that are critical in cancer biology and other diseases. This genetic model is particularly valuable in understanding how WDR48 influences cellular responses and might contribute to pathological conditions.
Scientific applications of WDR48 Gene Knockout Cell Lines are extensive, ranging from basic research in molecular and cellular biology to translational studies in important therapeutic areas. They are essential tools for elucidating the signaling pathways linked to immune response and cellular homeostasis. Moreover, these cell lines can be utilized in the screening of potential drug candidates aimed at restoring normal function or targeting specific cellular pathways altered by WDR48 inactivation.
One of the key advantages of our WDR48 Gene Knockout Cell Lines is their high specificity and reproducibility, which outperform traditional methods that may involve less precise genetic modification. Additionally, the utilization of these knockout models offers unparalleled consistency in experimental outcomes, enabling researchers to draw more reliable conclusions from their studies.
Ultimately, the value of WDR48 Gene Knockout Cell Lines to researchers and clinicians lies in their capability to reveal new insights into the roles of WDR48 in health and disease, potentially guiding the development of innovative therapeutic strategies. Our company's dedication to advancing genetic engineering technologies ensures that our product offerings meet the highest standards in research quality, providing scientists with powerful tools to unlock the complexities of cellular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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