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WASHC5 Knockout Cell Lines

Gene: WASHC5

Official Full Name: WASH complex subunit 5provided by HGNC

Gene Summary: This gene encodes a 134 kDa protein named strumpellin that is predicted to have multiple transmembrane domains and a spectrin-repeat-containing domain. This ubiquitously expressed gene has its highest expression in skeletal muscle. The protein is named for Strumpell disease; a form of hereditary spastic paraplegia (HSP). Spastic paraplegias are a diverse group of disorders in which the autosomal dominant forms are characterized by progressive, lower extremity spasticity caused by axonal degeneration in the terminal portions of the longest descending and ascending corticospinal tracts. More than 30 loci (SPG1-33) have been implicated in hereditary spastic paraplegia diseases. [provided by RefSeq, Aug 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32555 WASHC5 Knockout cell line (HeLa) Human WASHC5 1:3~1:6 Negative Online Inquiry
KO32556 WASHC5 Knockout cell line (HCT 116) Human WASHC5 1:2~1:4 Negative Online Inquiry
KO32557 WASHC5 Knockout cell line (HEK293) Human WASHC5 1:3~1:6 Negative Online Inquiry
KO32558 WASHC5 Knockout cell line (A549) Human WASHC5 1:3~1:4 Negative Online Inquiry

Background

WASHC5 Gene Knockout Cell Lines are genetically engineered cell lines that have been specifically modified to disrupt the WASHC5 gene, which encodes a component critical for the regulation of endosomal sorting and cytoskeletal remodeling. The knockout of the WASHC5 gene allows researchers to study the functional implications of its absence, particularly in cellular processes such as endocytosis, cytokinesis, and signal transduction pathways. This knockout model offers a powerful platform to elucidate the role of WASHC5 in various cellular functions and to investigate its influence on disease processes, including cancer and neurodegenerative disorders.

Key mechanisms involved include the alteration of endosome dynamics and changes in actin filament organization, which can lead to functional consequences at the cellular and organismal levels. By utilizing WASHC5 Gene Knockout Cell Lines, researchers can gain insights into how perturbations in endosomal trafficking contribute to pathophysiological conditions and uncover potential therapeutic targets.

The scientific importance of these cell lines is manifold; they serve as vital tools in both basic and applied research settings. In clinical contexts, understanding the role of WASHC5 in disease mechanisms can aid in the development of novel therapeutics and targeted interventions. Moreover, these knockout lines facilitate high-throughput screening and validations of gene functions, thereby accelerating research timelines.

What sets WASHC5 Gene Knockout Cell Lines apart from alternative models is their specificity and validated knockout efficiency, ensuring that researchers obtain reliable results. With comprehensive characterization and user-friendly protocols, these cell lines are designed to integrate seamlessly into existing workflows.

For researchers and clinicians dedicated to advancing their understanding of intracellular processes and disease mechanisms, WASHC5 Gene Knockout Cell Lines represent a valuable resource. Our company specializes in the development and provision of high-quality biological products, ensuring that scientists have access to cutting-edge tools that empower their groundbreaking research efforts.

Please note that all services are for research use only. Not intended for any clinical use.

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