Gene: Vav3
Official Full Name: vav 3 oncogeneprovided by MGI
Gene Summary: Enables epidermal growth factor receptor binding activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including integrin-mediated signaling pathway; neutrophil chemotaxis; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; limb segment; metanephros; and sensory organ. Orthologous to human VAV3 (vav guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00268 | Vav3 gRNA1-gRNA2 KO plasmid | Vav3 | $850 | |||
GP00368 | Vav3 gRNA3-gRNA4 KO plasmid | Vav3 | $850 | |||
KO01163 | Vav3 Knockout cell line(C2C12) | Mouse | Vav3 | 1:3~1:4 | Negative | Online Inquiry |
Vav3 Gene Knockout Cell Lines are specialized genetically modified cell lines designed to study the functional role of the Vav3 gene, a crucial regulator involved in cellular signaling pathways. With the precise knockout of the Vav3 gene, these cell lines provide researchers with a powerful tool to dissect the physiological and pathological implications of Vav3 in various biological processes, including cell migration, adhesion, and proliferation.
These cell lines operate through the disruption of the Vav3 gene using techniques such as CRISPR-Cas9 or traditional homologous recombination, ensuring the absence of functional protein. This specific genetic modification allows for the assessment of Vav3's impact on downstream signaling pathways, which can reveal critical insights into cancer progression, immune response, and neurodevelopmental disorders. Researchers can use these knockout models to elucidate cellular mechanisms and explore therapeutic targets in disease contexts.
The scientific importance of Vav3 Gene Knockout Cell Lines is underscored by their application in both basic research and translational studies. In research settings, they enable the identification of novel signaling pathways and cellular interactions, while in clinical contexts, they may facilitate the development of targeted therapies aimed at conditions where Vav3 signaling is misregulated.
Compared to alternative models that may exhibit off-target effects or incomplete gene disruption, Vav3 Gene Knockout Cell Lines provide a high degree of specificity and reliability. This purity ensures that experimental outcomes can be confidently attributed to the absence of Vav3, enhancing the reproducibility of research findings.
For researchers and clinicians looking to advance their understanding of Vav3-related functions in health and disease, these knockout cell lines offer unparalleled value. By leveraging our extensive expertise in genetic engineering and cellular biology, we provide high-quality products that empower scientific exploration and innovation. Our commitment to rigorous quality control and customer support ensures that users can maximize the potential of their research endeavors with Vav3 Gene Knockout Cell Lines.
Please note that all services are for research use only. Not intended for any clinical use.
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