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VWA1 Knockout Cell Lines

Gene: VWA1

Official Full Name: von Willebrand factor A domain containing 1provided by HGNC

Gene Summary: VWA1 belongs to the von Willebrand factor (VWF; MIM 613160) A (VWFA) domain superfamily of extracellular matrix proteins and appears to play a role in cartilage structure and function (Fitzgerald et al., 2002 [PubMed 12062410]).[supplied by OMIM, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12634 VWA1 Knockout cell line (HCT 116) Human VWA1 1:2~1:4 Negative Online Inquiry
KO12635 VWA1 Knockout cell line (HEK293) Human VWA1 1:3~1:6 Negative Online Inquiry
KO12636 VWA1 Knockout cell line (A549) Human VWA1 1:3~1:4 Negative Online Inquiry

Background

VWA1 Gene Knockout Cell Lines are specialized cell models engineered to lack the functional VWA1 gene, which encodes for the von Willebrand Factor type A domain-containing protein 1. This innovative product enables researchers to explore the specific biological functions and pathways associated with the VWA1 gene, thus facilitating a deeper understanding of its role in cellular processes such as adhesion, migration, and signal transduction.

The key mechanism behind VWA1 Gene Knockout Cell Lines involves CRISPR/Cas9 gene-editing technology that precisely targets and disrupts the VWA1 gene sequence. This knockout approach allows scientists to study the phenotypic consequences of VWA1 deficiency, examining how the absence of this gene impacts cellular behavior and interaction with the extracellular matrix. This tool serves as a powerful method for elucidating both normal and aberrant biological functions related to VWA1.

The scientific importance of VWA1 Gene Knockout Cell Lines is profound, particularly in the context of biomedical research where understanding the mechanisms of diseases such as cancer, thrombosis, and autoimmune disorders is critical. By providing a reliable model for in vitro experimentation, these knockout cell lines can advance therapeutic strategies and improve disease diagnostics.

One of the standout advantages of our VWA1 Gene Knockout Cell Lines is their high specificity and reliability, compared to more traditional methods of gene disruption. Our products are validated and quality-assured through extensive characterization, ensuring reproducibility and enhancing experimental outcomes. Unlike transient knockdown methods that may result in temporary gene suppression, our stable knockout lines provide sustained and reliable expression profiles, making them invaluable for long-term studies.

Researchers and clinicians seeking to expand their understanding of the VWA1 gene's function or explore its therapeutic potential will find these knockout cell lines exceptionally valuable. By providing a comprehensive tool for mechanistic studies, our product not only aids in the exploration of fundamental biological processes but also supports the development of novel interventions.

With a strong commitment to innovation and excellence in biological research tools, our company leverages cutting-edge technology to deliver high-quality gene knockout models, ensuring that researchers have access to the best resources for their scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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