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VRK2 Knockout Cell Lines

Gene: VRK2

Official Full Name: VRK serine/threonine kinase 2provided by HGNC

Gene Summary: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05260 VRK2 Knockout cell line (HeLa) Human VRK2 1:3~1:6 Negative Online Inquiry
KO05261 VRK2 Knockout cell line (HCT 116) Human VRK2 1:2~1:4 Negative Online Inquiry
KO05262 VRK2 Knockout cell line (HEK293) Human VRK2 1:3~1:6 Negative Online Inquiry
KO05263 VRK2 Knockout cell line (A549) Human VRK2 1:3~1:4 Negative Online Inquiry

Background

VRK2 Gene Knockout Cell Lines are specialized cellular models in which the VRK2 gene, known for its role in the regulation of cell proliferation and DNA repair, has been deliberately disrupted or deleted. This genetic modification allows researchers to study the functional consequences of VRK2 loss in a controlled environment, providing insights into cellular processes and pathophysiological conditions associated with abnormal VRK2 activity.

The primary function of these cell lines lies in their ability to mimic conditions seen in disease states, particularly those related to cancer and neurodegenerative disorders. By utilizing CRISPR-Cas9 technology, VRK2 gene knockout cell lines facilitate the investigation of downstream signaling pathways, cellular responses to stress, and mechanisms of tumorigenesis. This knockout model aids in understanding the critical role of VRK2 in maintaining genomic stability and its implications in various malignancies.

The scientific importance of VRK2 Gene Knockout Cell Lines is evident in both research and clinical applications, where they serve as invaluable tools for drug discovery and development. By providing a platform for high-throughput screening of therapeutic compounds, these models enable the identification of targeted treatments that can effectively modulate VRK2-associated pathways. Additionally, they support studies aimed at elucidating gene functions and interactions, paving the way for innovative approaches in gene therapy.

Compared to traditional genetic manipulation techniques, VRK2 Gene Knockout Cell Lines offer a more precise and efficient alternative, minimizing off-target effects and enhancing reproducibility. Moreover, their ease of use allows for rapid experimental design, making them an essential resource for both academic and industrial laboratories.

The value of VRK2 Gene Knockout Cell Lines is underscored by their ability to advance our understanding of complex biological systems while accelerating the translational application of research findings in a clinical context. As a company specializing in innovative biotechnological solutions, we are committed to providing high-quality genetic models that empower researchers to push the boundaries of science and medicine. Our expertise ensures that every product we offer meets the highest standards of reliability and efficacy, fostering groundbreaking discoveries in the ever-evolving field of cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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