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VPS50 Knockout Cell Lines

Gene: VPS50

Official Full Name: VPS50 subunit of EARP/GARPII complexprovided by HGNC

Gene Summary: Enables SNARE binding activity. Acts upstream of or within endocytic recycling. Located in recycling endosome. Part of EARP complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12641 VPS50 Knockout cell line (HeLa) Human VPS50 1:3~1:6 Negative Online Inquiry
KO12642 VPS50 Knockout cell line (HCT 116) Human VPS50 1:2~1:4 Negative Online Inquiry
KO12643 VPS50 Knockout cell line (HEK293) Human VPS50 1:3~1:6 Negative Online Inquiry
KO12644 VPS50 Knockout cell line (A549) Human VPS50 1:3~1:4 Negative Online Inquiry

Background

VPS50 Gene Knockout Cell Lines are a specialized model system designed to facilitate in-depth investigation of the VPS50 gene's role in cellular processes through targeted gene knockout techniques. These cell lines are engineered using CRISPR/Cas9 technology to create precise deletions of the VPS50 gene, which is implicated in various biological functions, particularly in endosomal trafficking and lysosomal function. The VPS50 gene encodes a protein that is essential for proper cellular homeostasis and plays a significant role in intracellular signaling and protein sorting.

The key function of VPS50 knockout cell lines lies in their ability to elucidate the consequences of VPS50 gene deletion on cellular mechanisms. Researchers employ these cell lines to explore altered pathways in endocytosis and exocytosis, providing critical insights into diseases where VPS50 malfunction is implicated, such as neurodegenerative disorders and certain cancers. These models serve as essential tools in both basic biological research and therapeutic investigation, helping scientists to delineate the gene's functional landscape and identify potential intervention points for novel treatments.

The scientific importance of VPS50 Gene Knockout Cell Lines extends to their applications in drug discovery and mechanistic studies. Compared to traditional knockout techniques, the CRISPR/Cas9 approach used in generating these cell lines offers a higher degree of specificity and efficiency, minimizing off-target effects and enhancing reproducibility in experiments. This precision allows researchers to confidently attribute observed phenotypic changes directly to the VPS50 knockout.

For researchers and clinicians focused on genetic and cellular dynamics, these knockout cell lines provide a unique advantage, enabling high-throughput screenings and pathway elucidation while fostering burgeoning fields such as gene therapy and regenerative medicine. They represent a critical leap forward from previous models, ensuring that users can derive clear, actionable insights for their investigations.

As a leader in providing advanced biological research tools, our company is committed to supporting scientific discovery through innovative products like VPS50 Gene Knockout Cell Lines. Our expertise in biotechnological advancements ensures that you receive high-quality, reliable resources that foster groundbreaking research and encourage scientific exploration.

Please note that all services are for research use only. Not intended for any clinical use.

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