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VPS39 Knockout Cell Lines

Gene: VPS39

Official Full Name: VPS39 subunit of HOPS complexprovided by HGNC

Gene Summary: This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29420 VPS39 Knockout cell line (HeLa) Human VPS39 1:3~1:6 Negative Online Inquiry
KO29421 VPS39 Knockout cell line (HCT 116) Human VPS39 1:2~1:4 Negative Online Inquiry
KO29422 VPS39 Knockout cell line (HEK293) Human VPS39 1:3~1:6 Negative Online Inquiry
KO29423 VPS39 Knockout cell line (A549) Human VPS39 1:3~1:4 Negative Online Inquiry

Background

VPS39 Gene Knockout Cell Lines are genetically engineered cell models specifically designed to study the functional roles of the VPS39 gene, which encodes a key protein involved in the endolysosomal trafficking system. This critical biological pathway is essential for maintaining cellular homeostasis, protein degradation, and signal transduction. By introducing targeted deletions in the VPS39 gene, these knockout cell lines provide researchers with a powerful tool to elucidate the physiological and pathological roles of this gene in a variety of biological contexts.

These cell lines operate through the absence of functional VPS39 protein, leading to altered cellular dynamics which can substantially impact cellular processes such as autophagy, lysosomal function, and even implicate roles in neurodegenerative diseases. The unique mechanism of action facilitated by these knockout cells allows for precise investigations into the VPS39 gene's involvement in cellular events, enabling the exploration of potential therapeutic strategies aimed at mitigating diseases linked to dysfunctional endosomal pathways.

The scientific importance of VPS39 Gene Knockout Cell Lines extends to various applications, including drug discovery, gene therapy research, and fundamental studies in cell biology. These models enhance the understanding of disease mechanisms and can accelerate the development of novel therapeutic approaches tailored to target specific cellular dysfunctions associated with VPS39.

Compared to other gene knockout models, VPS39 Gene Knockout Cell Lines offer unique advantages such as high specificity, reproducibility, and the ability to be easily manipulated alongside various experimental conditions. Our knockout lines are rigorously validated and characterized to ensure that they authentically replicate the absence of VPS39 protein, providing you with the confidence that your research will yield meaningful and reliable results.

For researchers and clinicians seeking to explore the intricacies of endolysosomal trafficking or disease mechanisms related to the VPS39 gene, these knockout cell lines represent an invaluable resource. Their ability to enhance experimental design and elucidate complex biological interactions provides significant value in advancing research objectives.

Our company is dedicated to providing high-quality biological products that foster groundbreaking scientific discoveries. With extensive expertise in gene editing technologies and a commitment to innovation, we are proud to offer VPS39 Gene Knockout Cell Lines as part of our robust product lineup, tailored to meet the diverse needs of the research community.

Please note that all services are for research use only. Not intended for any clinical use.

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