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VPREB3 Knockout Cell Lines

Gene: VPREB3

Official Full Name: V-set pre-B cell surrogate light chain 3provided by HGNC

Gene Summary: The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27033 VPREB3 Knockout cell line (HEK293) Human VPREB3 1:3~1:6 Negative Online Inquiry

Background

VPREB3 Gene Knockout Cell Lines are advanced cellular models specifically designed to study the function of the VPREB3 gene, an essential component of the immune system involved in the development and maturation of B cells. By utilizing CRISPR-Cas9 gene editing technology, these cell lines enable researchers to create precise deletions of the VPREB3 gene, thereby providing powerful tools to investigate the molecular mechanisms by which this gene contributes to immune responses and B cell-related diseases.

The key functions of the VPREB3 Gene Knockout Cell Lines include facilitating studies on B cell differentiation, signal transduction, and the assessment of immune system dysregulation, particularly in conditions such as immunodeficiency disorders and certain lymphomas. The knockout model allows for the observation of phenotypic changes following the loss of VPREB3, enhancing our understanding of its role in pathophysiology and potential therapeutic targets.

Scientific importance is underscored by the implications of VPREB3 in clinical settings such as developing novel immunotherapies and diagnostics for B cell malignancies. The ability to elucidate the impact of VPREB3 absence on cellular behavior opens avenues for targeted research and biomarker discovery, thereby accelerating the development of innovative treatments.

What sets VPREB3 Gene Knockout Cell Lines apart from traditional models is their state-of-the-art gene-editing precision, reproducibility, and a user-friendly framework for high-throughput applications. Unlike conventional methods that may introduce off-target effects or lack specificity, our cell lines ensure reliable results that bolster experimental integrity.

For researchers and clinicians, the value of these knockout cell lines is immeasurable; they support essential discoveries, drive clinical advancements, and enhance our collective understanding of immune mechanisms. By integrating cutting-edge technology with comprehensive support, we reaffirm our commitment to providing high-quality biological products and empowering scientific exploration. Our company stands at the forefront of genetic research tools, dedicated to advancing the fields of immunology and cellular biology through innovative solutions like the VPREB3 Gene Knockout Cell Lines.

Please note that all services are for research use only. Not intended for any clinical use.

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