Gene: VASP
Official Full Name: vasodilator stimulated phosphoproteinprovided by HGNC
Gene Summary: Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08706 | VASP Knockout cell line (HeLa) | Human | VASP | 1:3~1:6 | Negative | Online Inquiry |
KO08707 | VASP Knockout cell line (HCT 116) | Human | VASP | 1:2~1:4 | Negative | Online Inquiry |
KO08708 | VASP Knockout cell line (HEK293) | Human | VASP | 1:3~1:6 | Negative | Online Inquiry |
KO08709 | VASP Knockout cell line (A549) | Human | VASP | 1:3~1:4 | Negative | Online Inquiry |
VASP Gene Knockout Cell Lines are genetically engineered cellular models where the VASP (Vasodilator-Stimulated Phosphoprotein) gene has been selectively inactivated. This powerful research tool enables scientists to explore the role of VASP in various biological processes, including cell motility, cytoskeletal organization, and signal transduction pathways. By providing a method to study the functional consequences of VASP disruption, these knockout cell lines facilitate a deeper understanding of its contributions to cellular behavior in physiological and pathological contexts.
The primary mechanism that VASP gene knockout cell lines enable research involves studying the downstream effects of VASP deletion. By analyzing how the absence of this protein affects actin dynamics and cell migration, researchers can uncover the molecular pathways that VASP influences, which are crucial for processes such as wound healing, immune response, and cancer metastasis. These models serve as essential platforms for both in vitro and in vivo studies, leading to significant insights in cell biology and therapeutic development.
The scientific importance of VASP gene knockout cell lines extends to various applications in research, including the study of cardiovascular diseases, cancer biology, and neurobiology, where VASP's regulatory role is of great interest. Compared to other gene-editing methodologies, our knockout cell lines offer a reliable and reproducible means for researchers to assess gene function without the complications associated with off-target effects inherent in some CRISPR and RNAi techniques.
The unique selling points of these cell lines include their robust characterization, stability, and ease of use, which empower researchers to generate consistent and reliable data. Furthermore, the VASP gene knockout cell lines are adaptable to various experimental conditions, making them invaluable tools for validating hypotheses in numerous studies.
In a competitive research environment, the ability to precisely manipulate gene expression and function is invaluable. The VASP Gene Knockout Cell Lines provide a reliable and scientifically robust solution for researchers and clinicians aiming to elucidate the biological roles of VASP in health and disease. Our company prides itself on delivering high-quality biological products backed by extensive expertise in genetic engineering and cell culture technologies, ensuring our customers have access to the best tools for their groundbreaking research.
Please note that all services are for research use only. Not intended for any clinical use.
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