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VANGL1 Knockout Cell Lines

Gene: VANGL1

Official Full Name: VANGL planar cell polarity protein 1provided by HGNC

Gene Summary: This gene encodes a member of the tretraspanin family. The encoded protein may be involved in mediating intestinal trefoil factor induced wound healing in the intestinal mucosa. Mutations in this gene are associated with neural tube defects. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11636 VANGL1 Knockout cell line (HeLa) Human VANGL1 1:3~1:6 Negative Online Inquiry
KO11637 VANGL1 Knockout cell line (HCT 116) Human VANGL1 1:2~1:4 Negative Online Inquiry
KO11638 VANGL1 Knockout cell line (HEK293) Human VANGL1 1:3~1:6 Negative Online Inquiry
KO11639 VANGL1 Knockout cell line (A549) Human VANGL1 1:3~1:4 Negative Online Inquiry

Background

VANGL1 Gene Knockout Cell Lines are specially engineered cellular models developed to elucidate the functional roles of the VANGL1 gene, which plays a pivotal part in cellular processes such as planar cell polarity, embryonic development, and tissue homeostasis. These knockout cell lines are generated using advanced gene-editing techniques, including CRISPR-Cas9, to precisely disrupt the VANGL1 gene, allowing for a clear assessment of its biological impact.

The key mechanism of these knockout cell lines lies in their ability to facilitate in vivo and in vitro studies that reveal the consequences of VANGL1 loss on cellular behavior, signaling pathways, and morphological changes. By removing the genetic component responsible for coding the VANGL1 protein, researchers can investigate the gene's functional network, how it interacts with other cellular components, and its implications in various disease states, particularly in cancer and developmental disorders.

The scientific importance of VANGL1 Gene Knockout Cell Lines extends across multiple research domains. In clinical settings, understanding the pathophysiology associated with altered VANGL1 signaling can aid in the identification of novel therapeutic targets. Furthermore, these models are invaluable for drug discovery and validation processes, where insights into gene function can inform treatment strategies and improve patient outcomes.

Compared to alternative models, such as wild-type cell lines or other gene knockouts, VANGL1 Gene Knockout Cell Lines offer specificity in studying the VANGL1-related pathways without the confounding effects of other genes. This precise targeting enhances the reliability and validity of experimental results, making these cell lines essential tools for researchers seeking to advance their understanding of complex biological systems.

For researchers and clinicians focused on the intricacies of cell signaling and developmental biology, the value of VANGL1 Gene Knockout Cell Lines is tremendous. They provide a unique platform for exploratory research and hypothesis testing that can lead to significant breakthroughs in the fields of genetics, molecular biology, and oncology.

Our company possesses extensive expertise in the development of high-quality genetic models, ensuring that researchers have access to reliable, actionable tools that can enhance their scientific endeavors. Through our commitment to innovation and excellence, we enable the life sciences community to push the boundaries of knowledge and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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