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USP54 Knockout Cell Lines

Gene: USP54

Official Full Name: ubiquitin specific peptidase 54provided by HGNC

Gene Summary: Enables cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination and proteolysis. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12719 USP54 Knockout cell line (HeLa) Human USP54 1:3~1:6 Negative Online Inquiry
KO12720 USP54 Knockout cell line (HCT 116) Human USP54 1:2~1:4 Negative Online Inquiry
KO12721 USP54 Knockout cell line (HEK293) Human USP54 1:3~1:6 Negative Online Inquiry
KO12722 USP54 Knockout cell line (A549) Human USP54 1:3~1:4 Negative Online Inquiry

Background

USP54 Gene Knockout Cell Lines are specialized cell lines that have undergone targeted gene knockout of the USP54 gene via advanced CRISPR/Cas9 technology. USP54, or Ubiquitin-Specific Peptidase 54, is involved in the regulation of protein degradation pathways critical for cellular homeostasis. These knockout cell lines serve as valuable tools for studying the role of USP54 in various biological processes, including apoptosis, cell signaling, and responses to stress.

The key function of USP54 Gene Knockout Cell Lines lies in their ability to facilitate the examination of the effects of USP54 loss on cellular behavior. By eliminating this gene, researchers can investigate how the absence of its regulatory effects influences protein turnover and stability, thereby offering insights into cellular mechanisms that may contribute to disease pathogenesis or therapeutic resistance. This makes the cell lines indispensable for research focused on cancer biology, neurodegenerative disorders, and other conditions influenced by protein homeostasis.

In terms of scientific applicability, these cell lines are instrumental in validating hypotheses about gene function, enabling the identification of novel therapeutic targets. Their relevance extends to both preclinical and clinical research settings, where understanding the interaction between USP54 and other molecular pathways can inform drug development processes and enhance treatment strategies.

Unique advantages of USP54 Gene Knockout Cell Lines include their high specificity and consistency, ensuring repeatability in experimental results. Compared to traditional methods for gene disruption, the CRISPR/Cas9-mediated approach delivers precise genetic modifications swiftly and effectively, allowing for a streamlined research process. Furthermore, the robustness of these cell lines supports their integration into high-throughput screening platforms, optimizing the quest for new biomarkers and drug candidates.

Researchers and clinicians can maximize the impact of their studies by utilizing USP54 Gene Knockout Cell Lines, as they provide a critical understanding of molecular pathways that govern health and disease. The ability to reliably dissect gene function in controlled environments enhances both the scope of basic research and potential therapeutic advancements.

Our company, with a proven track record in genetic engineering and cell line development, emphasizes quality and innovation. We are committed to equipping scientists and healthcare professionals with the precision tools they need to push the boundaries of biological research and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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